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Diversity oriented synthesis based on the brevianamide scaffold for the development of physiologically active compounds (3F001011)

The diketopiperazine scaffold is a preferred (sub)structure in a wide variety of physiologically active natural compounds, including brevianamide F (antibacterial), present in Streptomyces and Aspergillus species. The project aims at the synthesis of heterodiketopiperazine analogues with a less complicated structure than the active natural compounds or the synthesis of diketopiperazines with medicinal relevant substituents starting from amino acids.

Date:1 Oct 2011  →  30 Sep 2015
Keywords:proline, diketopiperazine, tryptophane, brevianamide
Disciplines:Organic chemistry