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Project
Development of an Orthogonal Expression system in yeast for efficient microbial product synthesis (OrthoExpress) (Ortho-Express)
The main goal of this ConcepTT project is the development and patenting of a generic and independent expression system for (heterologous) genes in yeast to improve (industrial) fermentation processes. This system will act independent (orthogonal) to the native regulation system in yeast by decoupling gene expression from metabolic regulation. Validation of the new technology will occur by the production of the human milk oligosaccharide LNnT as case study.
Date:16 Apr 2019 → 31 Dec 2020
Keywords:Yeast, Orthogonal Expression System, Sustainable Production, Biotechnology, Fermentation, Human Milk Oligosaccharides
Disciplines:Genomics, Transcription and translation, Sustainable and environmental engineering not elsewhere classified, Genome structure and regulation, Carbohydrates, Microbiology not elsewhere classified, Bioprocessing, bioproduction and bioproducts, Regulation of metabolism, Genetics, Other biotechnology, bio-engineering and biosystem engineering not elsewhere classified, Fermentation, Industrial microbiology, Synthetic biology