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Development of KRN 7000 analogues with an improvement selectivity profile (3F003407)

Synthesis of alfa-galactosylceramide (KRN 7000) analogues with potential induction of a polarised cytokine respons (Th1 or Th2) by NKT cells. The proposed modifications intend an improved bindingafffinity with the CD1d protein. This should result in a bias towards a Th1 respons.

Date:1 Oct 2007  →  30 Sep 2010
Keywords:NKT cells, synthese, KRN 7000
Disciplines:Other pharmaceutical sciences, Pharmacognosy and phytochemistry, Organic chemistry, Drug discovery and development, Biomarker discovery and evaluation, Medicinal products, Toxicology and toxinology, Pharmacotherapy, Pharmacology, Pharmaceutics