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Design and development of molecular imprinted polymers with high affinity to the template based on one building block. (R-1834)

This research focuses specifically on developing new synthesis routes to synthesize Molecular Imprinted Polymers (MIPs). MIPs are synthetic polymeric analogues of anti-bodies, ie molecules that can serve as a receptor for other molecules. Therefore, they are a possible component of a sensor system for biomolecules. By using a "template molecule" in the presence of all components to synthesize the MIP, a nano-porous matrix with an affinity for the used "template molecule" is obtained. We aim developing methods that reduce the heterogeneity of binding sites, such that MIPs can be created with a higher selectivity and specificity in addition to a higher capacity. We wish to achieve this through involving the crosslinker more actively in the binding of the "template" molecule. This will be done by the synthesis of multifunctional crosslinkers involving the functional group, which is responsible for polymerization, and other functional groups who play an active role in the delivery of the weak interactions for the binding of the "template".
Date:1 Oct 2009  →  31 Jan 2010
Disciplines:Chemical sciences