Deciphering the network that links nutrient signaling in yeast with growth potential, pH and Ca2+ homeostasis, ageing and lifespan, resistance and virulence.
Cells of all living organisms are equipped with complex signal transduction networks enabling to make appropriate changes in metabolism in response to environmental changes. In this project, our focus is on how several signaling pathways in brewer’s yeast and pathogenic fungi integrate to control traits like stress resistance, reserve carbohydrate metabolism, lipid metabolism, ageing and lifespan, drug tolerance and, in case of pathogenic fungi, also virulence. Central in the project are the mechanisms to maintain pH and calcium homeostasis and the integrity organelles. The project will provide valuable information and open new avenues for the identification of new drugs and the development of new therapeutic approaches to combat fungal infection but we will also provide a pilot study demonstrating the importance for disorders like lysosomal-storage disease and neurodegenerative disorders.