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Project

Critical periods and brain plasticity – astrocytes as key modulators of cortical wiring

Information processing in the mammalian brain is carried out by neurons. Although adaptations in patterns of neuronal connectivity were once thought limited to development, it is now accepted that connections can also be modified by sensory information and experience in adults (plasticity). In the case of injuries, such as stroke or damage to sensory organs, this adaptation is thought to underlie the (partial) regain of function often seen in patients. However, neurons are only one type of brain cell and information now suggests that other cell types also play critical functions. One of these cell types is the astrocyte, which is known to be essential for the formation of neuronal connections in juvenile animals. Our data suggests that these cells are also critical for sensory deprivation induced plasticity in the adult brain and that boosting astrocyte activity can enhance recovery after injury. However, the mechanisms underlying this process remain unknown. We aim to follow up our observations and dissect the mechanisms by which astrocytes promote plasticity. This will improve our understanding of basic brain function and may uncover novel strategies to boost recovery from sensory loss, injury and disease in humans.

Date:16 Aug 2021 →  8 Mar 2022
Keywords:astrocytes, plasticity
Disciplines:Cellular interactions and extracellular matrix
Project type:PhD project