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Credit for participation at a congres: TERMIS European Chapter Meeting 2019 - Griekenland: 27/05/2019 - 31/05/2019 (R-9798)

Osteoarthritis (OA) is a degenerative and inflammatory condition of synovial joints with irreversible loss of supportive cartilage matrix. Dental pulp stem cells (DPSCs) can be differentiated into cartilage-producing cells and secrete numerous growth factors associated with tissue repair and immunomodulation. Moreover, leukocyte- and platelet-rich fibrin (L-PRF), a blood-derived and clinically applied biomaterial, has recently emerged as a promising treatment in regenerative medicine due to its growth factor content and supportive fibrin matrix. The main goal of this study is to evaluate whether DPSCs and L-PRF are promising treatment strategies in OA via immunomodulation and stimulation of cartilage regeneration. Preliminary in vitro data show that DPSCs and L-PRF are a promising treatment option for OA via secretome-mediated effects. Our final goal is to test in vivo if DPSCs and L-PRF improve cartilage repair and have immunomodulatory effects in an ovine model of OA
Date:27 May 2019 →  31 May 2019
Disciplines:Cardiac and vascular medicine not elsewhere classified, Oral medicine and pathology, Diagnostic radiology, Anatomy