Concerto for solids and biocatalysts - Cascade biocatalysis and heterogeneous catalysis for fine chemicals production (ConSolid)

Scientific project objectives: 1. To design new solid catalysts for aliphatic amine racemization, and use them for dynamic kinetic resolution (DKR) of racemic aliphatic amines to enantiopure amides, preferably in a flow chemistry setting; Progress in comparison with state-of-the-art: there are so far no such racemisation catalysts known, resulting in a lack of methods for synthesis of enantiopure amides from racemic aliphatic amines via DKR.  2. To use innovative enzymes, like phenyl aminomutases (PAMs), in the context of a DKR, together with a racemization catalyst, allowing production of enantiopure non-natural amino acids. Progress in comparison with state-of-the-art: The opportunities to use PAM and related enzymes in DKR (together with solid catalysts) have so far not been exploited for synthesis of  antiopure amino acids.