Computational probing of replicative stress resistance and induced G-quadruplex resolving processes in embryonic stem or cancer cells

Fast dividing embryonic stem and cancer cells are subject to stress during DNA replication. G-quadruplexes (G4s) are DNA secondary structures formed by G-rich regions in the DNA, and have recently been shown to play a key role in embryonic stem cell and cancer cell replicative stress. I will apply in-depth bioinformatics analysis on this subject.