Complex genetics of Alzheimer's disease and related disorders.

Alzheimer's disease and related neurodegenerative brain diseases are strongly disabling and ultimately fatal. Due to changing demographics and in the current absence of a cure, these diseases pose a considerable threat to both personal and public health. This project proposes to come to a better understanding of these genetically complex diseases, and to translate this knowledge into useful tools for molecular diagnostics and risk prediction. To achieve this goal, the project is built on three pillars, a powerful well-documented study population, advanced molecular genetic techniques including next generation sequencing and genome-wide copy number variation detection, and state-of-the-art genetic epidemiological data analysis. Findings will be translated into markers for early diagnosis and molecular profiling, eventually enabling personalized causal treatment of these conditions.

Keywords:ALZHEIMER'S DISEASE, GENETICS, NEURODEGENERATIVE DISORDERS

Disciplines:Genetics, Systems biology, Molecular and cell biology, Public health care, Public health sciences, Public health services