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Combined dual transcriptomic, proteomic and functional investigations to reveal host-pathogen interactions behind the virulence of foodborne pathogen Bacillus cereus

A toxin-mediated infection of foodborne Bacillus cereus requires direct contact of viable B. cereus with its host for in-situ production of diarrheal enterotoxins. This direct contact leads to a cross-talk between a pathogen and its host. The interaction will be investigated by functional, cytotoxic and
transcriptomic approaches, using tools such as Seahorse flux analysis, RNAseq, microarrays, RTPCR, ELISA and mass-spectrometry.

Date:1 Jan 2022 →  30 Jun 2022
Keywords:host-pathogen interaction, proteomics, transport, virulence, cytotoxicity, RNAseq, transwell, Seahorse, transcriptome, bacillus cereus, microaaray, toxins
Disciplines:Food microbiology, Transcription and translation