Combined dual transcriptomic, proteomic and functional investigations to reveal host-pathogen interactions behind the virulence of foodborne pathogen Bacillus cereus

A toxin-mediated infection of foodborne Bacillus cereus requires direct contact of viable B. cereus with its host for in-situ production of diarrheal enterotoxins. This direct contact leads to a cross-talk between a pathogen and its host. The interaction will be investigated by functional, cytotoxic and transcriptomic approaches, using tools such as Seahorse flux analysis, RNAseq, microarrays, RT-PCR, ELISA and mass-spectrometry.