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Project

Causes of micro-inflammation and cardiovascular disease in chronic kidney disease: role of uremic peptides

Retention of uremic solutes as well as renal replacement therapy contribute to micro-inflammation related to the cardial burden in chronic kidney disease. Especially the effect of uremic peptides on leukocytes and specific leukocyte subpopulations will be evaluated in an in vitro set-up. The pathophysiological mechanisms involved, will be elucidated, aiming at a classification of the retention solutes according to their toxicity.

Date:1 Jan 2010 →  31 Dec 2015
Keywords:cardiovascular diseases, uremic retention solutes, inflammation
Disciplines:Urology and nephrology, Cardiac and vascular medicine, Biochemistry and metabolism, Medical biochemistry and metabolism