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The cascade effect of PFAAs in birds.
Perfluoroalkyl acids (PFAAs) are highly persistent substances that are found globally in the environment, wildlife and humans. Despite the ubiquity of PFAAs, their toxicological and biological effects have not yet been well characterized. We will assess the effects produced by PFAA compounds in a model species (i.e. canaries), at environmentally realistic concentrations, across different levels of biological organization. For this, we will use an integrative approach that combines the latest techniques in molecular biology with the study of traditional biomarkers. Moreover, behavioural parameters (song behaviour) will also be included in the approach, which has rarely been done in ecotoxicological studies. All this will further enable us to establish linkages between the key events in the biological cascade that lead to effects on the survival or reproduction of the individual. The obtained information will be organised and evaluated, together with existing knowledge, in a standardized way that makes it useful for regulatory purposes. The final construct (Adverse Outcome Pathway) will be presented to the OECD and will help to fill an important knowledge gap.
Date:1 Jan 2019 → Today