The calcification paradox: investigation into the mechanisms underlying the association between metabolic bone disease and vascular calcification.

Objectives:1. Investigation of the association between vascular calcification and histomorphometric bone changes in osteoporotic rats with normal and impaired renal function by means of serial in vivo micro-CT scan and histomorphometric analysis of the bone.2. Investigation of the role of the bone turnover rate and the effect of the bisphosphonate compound zoledronic acid on the development of uremia-related vascular calcification in different experimental models of renal osteodystrophy.

Keywords:HISTOMORPHOMETRY, VASCULAR CALCIFICATION, METABOLIC BONE DISEASE

Disciplines:Cardiac and vascular medicine, Medical imaging and therapy, Orthopaedics, Other paramedical sciences