< Back to previous page

Project

Bidirectional communication between the enteric nervous system and elements of the immune system in inflammatory gastrointestinal disorders.

In this project animal models were used to study the interaction between neuronal components of the GI tract and elements of the immune system, more particularly mast cells and dendritic cells, during inflammation. This interaction appears to play an important role in the inflammatory response and might offer a better insight for the observed hyperexcitability of afferent components of the enteric nervous system during gastrointestinal inflammation. This project will primarily focus on the possible role of cortistatin and urocortines in this interaction.
Date:1 Jan 2008 →  31 Dec 2011
Keywords:COLITIS, NEUROIMMUNOLOGY, ENTERIC NERVOUS SYSTEM, MAST CELLS
Disciplines:Gastro-enterology and hepatology, Morphological sciences