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Bacterial population heterogeneity
Even under homogeneous environmental conditions isogenic cells within a clonal bacterial population tend to display intercellular differences that can result in differential behaviour and survival. This project aims to understand the molecular-genetic mechanisms underlying this cellular individuality and population heterogeneity, as well as the corresponding phenotypic consequences.Additionally, the interaction with phages can result in an additional layer of bacterial heterogeneity. Through the so-called carrier state dynamics different subpopulations can emerge in an infected population, exhibiting a deviating phenotype from naive isogenic cells. This mechanism will be studied further.
Date:1 Oct 2019 → Today
Keywords:Population heterogeneity, Salmonella, Protein aggregates, Phages
Disciplines:Bacteriology, Food microbiology, Virology
Project type:PhD project