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Project

The association between motor skill learning and dynamics of GABA, synaptic density and connectivity in motor-related brain regions

Most everyday tasks require well-coordinated bimanual movements. Acquiring these skills is associated with neuroplastic processes, changes in neurotransmitter levels and synaptic density. However, the detailed neurobiological mechanisms underlying motor practice are still unclear. With this research project I aim to better understand the neurobiological mechanisms associated with motor skill practice, namely (1) the dynamics of GABA levels in the left dorsal premotor cortex; (2) structural changes in synaptic density; and (3) functional and structural connectivity changes. For this project, 40 healthy participants (18-35 years) will be recruited, of which 20 will undergo a 4-week training program of a complex bimanual coordination task (experimental group), while the other 20 perform a paradigm that does not require learning (control group). Motor practice-associated neurobiological changes will be investigated using a multimodal approach, combining medical imaging and neurophysiological techniques, including Positron Emission Tomography using a recently developed [11C]UCB-J tracer to measure synaptic density. Measurements will be conducted at baseline and at 2 and 4 weeks of motor practice. Using several cutting-edge technologies integrated into a multimodal approach, this comprehensive research project intends to deliver important novel insights into motor learningā€related neuroplasticity that may inspire clinical research on individualized neuromodulation strategies.

Date:4 Aug 2020 →  Today
Keywords:Motor control, Neuroplasticity, Multimodal neuroimaging
Disciplines:Nuclear imaging, Medical imaging and therapy not elsewhere classified, Neurophysiology, Behavioural neuroscience, Cognitive neuroscience
Project type:PhD project