Apoptosis associated lncRNAs in HIV-1 infection: new targets to selectively kill latent viral reservoirs.

HIV-1 integration inside the cell results in formation of a latent reservoir. An interesting approach to eliminate the latent HIV-1 reservoir is the so-called shock-and-kill method. For the shock part, competent agents have been described but an efficient killing mechanism is lacking. We will selectively target long non-coding RNAs linked to apoptosis to obtain this efficient killing mechanism.