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Project

Analysing the function of APP as Wnt signaling receptor and the relevance for the Alzheimer disease.

Alzheimer’s disease (AD) is the most common form of dementia among the elderly. Research in the
AD field has been mostly focused on the biology of the Ab peptide but increasing evidence is shifting
attention toward the physiological role of APP as key to understanding AD pathology. It is becoming
apparent that APP plays a central role in the mechanisms that guarantee the accuracy and the
robustness of brain wiring. Recently we found that APP is co-receptor for a major signal, called the
Wnt-PCP signal, that is needed for the brain to wire correctly. However, the precise details of how
APP works in transducing this signal are unclear. In this project we will explore these details and ask
if the function of APP as a Wnt co-receptor is relevant to Alzheimer's disease.

Date:1 Jan 2015 →  31 Dec 2018
Keywords:Alzheimer
Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences