Acute effects of low vs. high nicotine concentrations in liquids in e-cigarettes on self-titration, craving, and satisfaction

The effectiveness of the electronic cigarette (e-cig) for smoking cessation has extensively been investigated, but high-quality studies on possible moderating factors are lacking. An example of such a moderating factor is the nicotine concentrations that are used in the liquids. More specifically, the use of low nicotine concentrations can lead to self-titration or compensatory vaping behavior (increasing the number/duration of the puffs and the power of the e-cig). The main aim of the two cross-over experimental studies presented is to investigate the effect of the use of low vs. high nicotine concentrations on vaping behavior, both in smokers naive to e-cigs and in experienced e-cig users. With these studies we want to try to establish a proof of concept with respect to self-titration. In addition, any differences obtained between e-cig naive and experienced e-cig users can be used to guide further research.

Keywords:Electronic cigarettes, Nicotine, Tobacco Harm Reduction, Self-titration

Disciplines:Human experimental psychology not elsewhere classified, Clinical trials, Pharmacotherapy, Behavioural sciences