Aβ-Tau cascade promotes oxidative stress and genomic damage that drives neuronal cell loss: DNA repair mechanisms as therapeutic targets in Alzheimer disease (R-12562)

Accumulating evidence indicates that combinatorial strategies targeting pathways downstream of Aꞵ and Tau will be required to effectively halt the Alzheimer disease (AD) process. Here, we will investigate DNA repair mechanisms downstream of the Aꞵ-Tau cascade as critical mediators of neurodegeneration. We will determine the importance of aging hallmarks and DNA repair systems in AD etiology to design novel therapeutic approaches to effectively halt the disease.

Keywords:Alzheimer, Alzheimer disease and tauopathies, DNA Repair, Neurology, Neuronal cell death

Disciplines:Biogerontology, Nucleic acids, Molecular and cell biology not elsewhere classified, Cognitive neuroscience, Neurological and neuromuscular diseases, Cancer biology