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Patent

RNA transcription vector and uses thereof

The present invention relates to an improved RNA transcription vector, which is very suitable for the production of mRNA for in vivo therapeutic purposes. The improvements in the vector reside in the presence of a translation enhancer (TE) and a nuclear retention element (NRS), especially when the latter is the “Expression and Nuclear Retention Element” (ENE) of Kaposi's sarcoma associated Herpes virus (KSHV).
Patent Publication Number: US10159755
Year filing: 2018
Year approval: 2018
Validated for IOF-key: Yes
Attributed to: Universitaire Associatie Brussel