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Patent
Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease
The present application relates to the field of Parkinson's disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase PINK1. A new substrate for this kinase, NdufA10, is identified herein. In Parkinson's disease, this protein is dephosphorylated, which is linked to a loss of mitochondrial membrane potential. It is shown that restoring or mimicking phosphorylation of NdufA10 restores the phenotypic defects associated with Parkinson's disease and is thus a new therapeutic paradigm.
Patent Publication Number: US9879233
Year filing: 2018
Year approval: 2018
Year publication: 2018
Status: Assigned
URI: link to Espacenet
Technology domains: Pharmaceuticals, Basic materials chemistry
Validated for IOF-key: Yes
Attributed to: Associatie KULeuven