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Patent
RESTORING PHOSPHORYLATION OF A NOVEL PINK1 SUBSTRATE TO TREAT PARKINSON'S DISEASE
The present application relates to the field of Parkinson's disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase PINK1. A new substrate for this kinase, NdufA10, is identified herein. In Parkinson's disease, this protein is dephosphorylated, which is linked to a loss of mitochondrial membrane potential. It is shown that restoring or mimicking phosphorylation of NdufA10 restores the phenotypic defects associated with Parkinson's disease and is thus a new therapeutic paradigm.
Patent Publication Number: WO2014072412
Year filing: 2013
Year approval: 2015
Year publication: 2014
Status: Requested
URI: link to Espacenet
Technology domains: Biotechnology
Validated for IOF-key: Yes
Attributed to: Associatie KULeuven