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Patent
Drug-target identification by rapid selection of drug resistance mutations
The present invention relates to methods used in functional genomics that focus on gene function in a cell. The invention also relates to mutagenizing genes and generation of functional genetic mutants. The current invention also relates to methods for stimulus/drug-target identification. In addition, the invention relates to the generation of cell lines showing a functional phenotype, most notably stimulus/drug-resistant cell lines. The current invention further relates to methods for identification of mutations conferring this phenotype. The current invention further relates to said methods and provides for rapid selection methods to identify targets and to identify stimulus/drug-target interactions and to identify mutations conferring stimulus/drug-resistance, more specifically said methods comprise the use of CRISPR/Cas systems, components thereof or the like.
Patent Publication Number: WO2018032063
Year filing: 2017
Year approval: 2019
Year publication: 2018
Status: Requested
URI: link to Espacenet
Technology domains: Biotechnology
Validated for IOF-key: Yes
Attributed to: Associatie KULeuven