< Back to previous page
Organisation
Steyaert Lab
Research Group
Main organisation:VIB-VUB Center for Structural Biology
Lifecycle:1 Jan 2017 → Today
Organisation profile:Exploiting nanobodies for drug discovery on difficult targets like GPCRs and on the engineering of nanobodies to be used in single particle cryo-EM and OMICs applications.
Keywords:Molecular Biophysics, protein networks, Macromolecules, crystallography
Disciplines:Medicinal and biomolecular chemistry, Biochemistry and metabolism, Biophysics
Current researchers
1 - 10 of 22 results
- Jan Steyaert (Responsible)
- Marjolijn Berghmans (Member)
- Thomas Dal Maso (Member)
- Phebe De Keyser (Member)
- Babette Deckers (Member)
- Baptiste Fischer (Member)
- Galicia Christian (Member)
- Danae Giakoumakis (Member)
- Steven Janvier (Member)
- Valentina Kalichuk (Member)
Projects
1 - 9 of 9
- Integrated Services for Infectious Disease Outbreak Research (ISIDORe)From1 Feb 2022 → TodayFunding: Other EU initiatives out of framework
- VIB Grant for Steyaert Lab_Period:2022-01-01-2026-12-31From1 Jan 2022 → TodayFunding: FRI - Project driven research
- GBA stabilization and activation through nanobodies and derived peptide mimetics in neuronal modelsFrom1 Sep 2021 → TodayFunding: Foreign foundations, funds with scientific view
- GBA1 stabilization through nanobodies : a versatile tool to improve wild type and mutant enzyme functionFrom1 Aug 2019 → 31 Jan 2021Funding: Foreign foundations, funds with scientific view
- Biochemical and structural characterization of LRRK2-specific nanobodiesFrom27 Jul 2019 → 26 Jul 2021Funding: Foreign foundations, funds with scientific view
- Application of novel nanobodies to existing LRRK2 biomarker assays for the segregation of affected patients in multiple cohorts of familial and idiopathic PDFrom1 Dec 2018 → 30 Nov 2020Funding: Foreign foundations, funds with scientific view
- Conformation-specific nanobodies for biochemical, functional and structural characterization of LRRK2From15 Jun 2017 → 14 Jun 2019Funding: Foreign foundations, funds with scientific view
- VIB Grant for Steyaert Lab_Period:2017-01-01-2021-12-31From1 Jan 2017 → 31 Dec 2021Funding: FRI - Project driven research
- Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science researchFrom1 Jan 2017 → 31 Dec 2020Funding: Other EU initiatives out of framework
Publications
1 - 10 of 113
- A specific nanobody prevents amyloidogenesis of D76N beta2-microglobulin in vitro and modifies its tissue distribution in vivo(2017)
Authors: Els Pardon, Jan Steyaert
Pages: 46711 - Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges(2017)
Authors: Jan Steyaert
Pages: 735-741 - Single-particle cryo-EM at atomic resolution.(2020)
Authors: Tomasz Uchanski
Pages: 152-156 - GTP Binding is Necessary for the Activation of a Toxic Mutant Isoform of the Essential GTPase ObgE.(2020)
Authors: Liselot Dewachter, Babette Deckers, Ella Martin, Pauline Herpels, Sotirios Gkekas, Wim Versées, Natalie Verstraeten, Maarten Fauvart, Jan Michiels
Pages: 16 - Discussions on the quality of antibodies are no reason to ban animal immunization.(2020)
Authors: Jan Steyaert
Pages: e51761 - Challenges in the Structural-Functional Characterization of Multidomain, Partially Disordered Proteins CBP and p300: Preparing Native Proteins and Developing Nanobody Tools(2018)
Authors: Els Pardon, Jarne Pauwels, Kris Gevaert, Jan Steyaert, Stefaan Derveaux, Peter Tompa
Pages: 607-675 - Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion.(2019)
Authors: Alexandre Wohlkönig, Els Pardon, Jan Steyaert
Pages: e1008139 - A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations.(2020)
Authors: Jone Paesmans, Ella Martin, Babette Deckers, Marjolijn Berghmans, Ritika Sethi, Els Pardon, Jan Steyaert, Patrik Verstreken, Christian Galicia Diaz Santana, Wim Versées
Pages: e64922 - Identification of Nanobodies against the Acute Myeloid Leukemia Marker CD33.(2020)
Authors: Ema Romão, Laila Maes, Benoît Stijlemans, Cécile Vincke
- Structure of an endosomal signaling GPCR-G protein-ß-arrestin megacomplex.(2019)
Authors: Jan Steyaert
Pages: 1123-1131