Organisation
Research Group Molecular Neurobiology (VIB-KU Leuven)
Division
Major research questions focus on cell type vulnerability and single-cell heterogeneity, protein aggregation and proteopathic stress, synaptic function, as well as microglial activation and neuroimmunology.
Sub-organisation(s)
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- Laboratory of Proteolytic Mechanisms in Neurodegeneration (VIB-KU Leuven)
- Laboratory of Neuronal Communication (VIB-KU Leuven)
- Laboratory of Neuronal Differentiation (VIB-KU Leuven Center for Brain & Disease Research)
- Laboratory of Emotional Circuit Development (VIB-KU Leuven)
- Laboratory of Interneuron Developmental Dynamics (VIB-KU Leuven)
- Laboratory of Sleep and Synaptic Plasticity (VIB-KU Leuven)
- Laboratory of Membrane Trafficking (VIB-KU Leuven)
- Laboratory of Stem Cell and Developmental Neurobiology (VIB-KU Leuven)
- Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven)
- Laboratory of Glia Biology (VIB-KU Leuven)
Current researchers
1 - 7 of 7 results
- Patrik Verstreken (Responsible)
- Natalia Gunko (Member)
- Véronique Hendrickx (Member)
- Esther Klingler (Member)
- Sebastian Munck (Member)
- Nicolas Peredo (Member)
- Angéle Pouwels (Member)
Projects
1 - 10 of 22
- Replace a broken freeze substitution low temperature embedding system for light and electron microscopy (Leica EM AFS2)From1 Jan 2023 → TodayFunding: BOF - scientific equipment program
- Flanders BioImaging: Leading Imaging Application Integrated Service and Enablement (FBI-LIAISE)From1 Jan 2023 → TodayFunding: FWO International research infrastructure (IRI)
- Single-objective light sheet instrument for fast and highthroughput imaging of 3D tissueFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- 3D SUper-Resolution to cryo-Electron MIcroscopy to study nanoscale subcellular dynamics and structure that alter in Neurodegenerative Diseases - 3SURE MINDFrom1 May 2022 → TodayFunding: FWO Large scale research infrastructure
- FB-III (“FB triple-I”) : Flanders BioImaging: Integrating Imaging Infrastructure from cell to man.From1 Feb 2021 → TodayFunding: FWO International research infrastructure (IRI)
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- Development of new chemical tools to investigate the role of L-type calcium channels in diseases.From6 Oct 2020 → TodayFunding: FWO Strategic Basic Research Grant
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Development of an interdisciplinary platform for spatial multi-omic analysis of single cellsFrom1 Oct 2019 → 30 Sep 2023Funding: BOF - projects
- Structural bases of γ-secretase processivity in Familial Alzheimer's DiseaseFrom1 Feb 2019 → 1 Feb 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
31 - 40 of 168
- ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1(2011)
Authors: Aleksandar Peric, Lujia Zhou, Katrijn Coen, Sebastian Munck, Bart De Strooper, Wim Annaert
Pages: E559 - E568 - High-content analysis of α-synuclein aggregation and cell death in a cellular model of Parkinson's disease(2015)
Authors: Francesca Macchi, Chris Van den Haute, Sebastian Munck, Hans Pottel, Annelies Michiels, Zeger Debyser, Veerle Baekelandt
Pages: 117 - 127 - Maximizing content across scales: Moving multimodal microscopy and mesoscopy toward molecular imaging(2021)
Authors: Sebastian Munck, Greetje Vande Velde
Pages: 188 - 199 - The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation (vol 5, pg 1523, 2013)(2014)
Authors: Rossella Luca, Michele Averna, Francesca Zalfa, Manuela Vecchi, Fabrizio Bianchi, Giorgio La Fata, Franca Del Nonno, Roberta Nardacci, Marco Bianchi, Paolo Nuciforo, et al.
Pages: 567 - 567 - β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.(2013)
Authors: Amantha Thathiah, K Horré, A Snellinx, E Vandewyer, Yunhong Huang, M Ciesielska, G De Kloe, Sebastian Munck, Bart De Strooper
Pages: 43 - 49 - Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques(2021)
Authors: Pranav Preman, Sebastian Munck, Dietmar Thal, Bart De Strooper
- Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain(2017)
Authors: Ira Espuny Camacho, Mark Fiers, Sebastian Munck, Pierre Vanderhaeghen, Bart De Strooper
Pages: 1066 - 1081 - Machine learning-assisted fluoroscopy of bladder function in awake mice(2022)
Authors: Helene De Bruyn, Sebastian Munck, Wouter Everaerts, Thomas Voets
- Defective Sec61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia(2020)
Authors: Erika Van Nieuwenhove, Julika Neumann, Elien Smeets, Emanuela Pasciuto, Vasiliki Lagou, Laura Seldeslachts, Bert Malengier-Devlies, Mieke Metzemaekers, Rob van der Kant, Joost Schymkowitz, et al.
Pages: 1180 - 1193 - Role of PFKFB3-Driven Glycolysis in Vessel Sprouting(2013)
Authors: Katrien De Bock, Sandra Schoors, Anna Kuchnio, Brian Wong, Anna Rita Cantelmo, Annelies Quaegebeur, Bart Ghesquière, Guy Eelen, Ilse Geudens, Bert Cruys, et al.
Pages: 651 - 663