Organisation
Research Group Molecular Neurobiology (VIB-KU Leuven)
Division
Major research questions focus on cell type vulnerability and single-cell heterogeneity, protein aggregation and proteopathic stress, synaptic function, as well as microglial activation and neuroimmunology.
Sub-organisation(s)
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- Laboratory of Interneuron Developmental Dynamics (VIB-KU Leuven)
- Laboratory of Sleep and Synaptic Plasticity (VIB-KU Leuven)
- Laboratory of Proteolytic Mechanisms in Neurodegeneration (VIB-KU Leuven)
- Laboratory of Neuronal Communication (VIB-KU Leuven)
- Laboratory of Neuronal Differentiation (VIB-KU Leuven Center for Brain & Disease Research)
- Laboratory of Emotional Circuit Development (VIB-KU Leuven)
- Laboratory of Membrane Trafficking (VIB-KU Leuven)
- Laboratory of Stem Cell and Developmental Neurobiology (VIB-KU Leuven)
- Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven)
- Laboratory of Glia Biology (VIB-KU Leuven)
Current researchers
1 - 7 of 7 results
- Patrik Verstreken (Responsible)
- Natalia Gunko (Member)
- Véronique Hendrickx (Member)
- Esther Klingler (Member)
- Sebastian Munck (Member)
- Nicolas Peredo (Member)
- Angéle Pouwels (Member)
Projects
1 - 10 of 22
- Replace a broken freeze substitution low temperature embedding system for light and electron microscopy (Leica EM AFS2)From1 Jan 2023 → TodayFunding: BOF - scientific equipment program
- Flanders BioImaging: Leading Imaging Application Integrated Service and Enablement (FBI-LIAISE)From1 Jan 2023 → TodayFunding: FWO International research infrastructure (IRI)
- Single-objective light sheet instrument for fast and highthroughput imaging of 3D tissueFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- 3D SUper-Resolution to cryo-Electron MIcroscopy to study nanoscale subcellular dynamics and structure that alter in Neurodegenerative Diseases - 3SURE MINDFrom1 May 2022 → TodayFunding: FWO Large scale research infrastructure
- FB-III (“FB triple-I”) : Flanders BioImaging: Integrating Imaging Infrastructure from cell to man.From1 Feb 2021 → TodayFunding: FWO International research infrastructure (IRI)
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- Development of new chemical tools to investigate the role of L-type calcium channels in diseases.From6 Oct 2020 → TodayFunding: FWO Strategic Basic Research Grant
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Development of an interdisciplinary platform for spatial multi-omic analysis of single cellsFrom1 Oct 2019 → 30 Sep 2023Funding: BOF - projects
- Structural bases of γ-secretase processivity in Familial Alzheimer's DiseaseFrom1 Feb 2019 → 1 Feb 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
161 - 168 of 168
- Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface(2020)
Authors: Lucia Chavez Gutierrez, Sebastian Munck, Hideaki Mizuno, Wim Annaert
- The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation(2013)
Authors: Sebastian Munck, Anna Kuchnio, Bart De Strooper, Patrick Neven, Peter Carmeliet, Max Mazzone, Claudia Bagni
Pages: 1523 - 1536 - Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models(2015)
Authors: Yunhong Huang, Sebastian Munck, Rudi D'Hooge, Bart De Strooper, Amantha Thathiah
Pages: 309 - Adenosine induces growth-cone turning of sensory neurons(2008)
Authors: Sebastian Munck
Pages: 357 - 64 - Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool(2016)
Authors: Arunkumar Tharkeshwar Raghunath, Roger Habets, Rosanne Wouters, Sebastian Munck, Rita Derua, Etienne Waelkens, Mathieu Bollen, Joost Schymkowitz, Frederic Rousseau, Bart De Strooper, et al.
Pages: 193 - 208 - The mechanism of gamma-Secretase dysfunction in familial Alzheimer disease(2012)
Authors: Lucia Chavez Gutierrez, Leen Bammens, Annelies Vandersteen, Lujia Zhou, Eric Karran, Joost Schymkowitz, Frederic Rousseau, Bart De Strooper
Pages: 2261 - 2274 - KIF1B beta transports dendritically localized mRNPs in neurons and is recruited to synapses in an activity-dependent manner(2013)
Authors: Emanuela Pasciuto, Sebastian Munck, Claudia Bagni
Pages: 335 - 356 - Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling(2019)
Authors: Nicolas Peredo, Sebastiaan Vanuytven, Koen Theunis, Thierry Voet, Christa Maes
Pages: 236 - +