Organisation
Research Group Molecular Neurobiology (VIB-KU Leuven)
Division
Major research questions focus on cell type vulnerability and single-cell heterogeneity, protein aggregation and proteopathic stress, synaptic function, as well as microglial activation and neuroimmunology.
Sub-organisation(s)
1 - 10 of 14
- Laboratory of Interneuron Developmental Dynamics (VIB-KU Leuven)
- Laboratory of Sleep and Synaptic Plasticity (VIB-KU Leuven)
- Laboratory of Proteolytic Mechanisms in Neurodegeneration (VIB-KU Leuven)
- Laboratory of Neuronal Communication (VIB-KU Leuven)
- Laboratory of Neuronal Differentiation (VIB-KU Leuven Center for Brain & Disease Research)
- Laboratory of Emotional Circuit Development (VIB-KU Leuven)
- Laboratory of Membrane Trafficking (VIB-KU Leuven)
- Laboratory of Stem Cell and Developmental Neurobiology (VIB-KU Leuven)
- Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven)
- Laboratory of Glia Biology (VIB-KU Leuven)
Current researchers
1 - 7 of 7 results
- Patrik Verstreken (Responsible)
- Natalia Gunko (Member)
- Véronique Hendrickx (Member)
- Esther Klingler (Member)
- Sebastian Munck (Member)
- Nicolas Peredo (Member)
- Angéle Pouwels (Member)
Projects
1 - 10 of 22
- Replace a broken freeze substitution low temperature embedding system for light and electron microscopy (Leica EM AFS2)From1 Jan 2023 → TodayFunding: BOF - scientific equipment program
- Flanders BioImaging: Leading Imaging Application Integrated Service and Enablement (FBI-LIAISE)From1 Jan 2023 → TodayFunding: FWO International research infrastructure (IRI)
- Single-objective light sheet instrument for fast and highthroughput imaging of 3D tissueFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- 3D SUper-Resolution to cryo-Electron MIcroscopy to study nanoscale subcellular dynamics and structure that alter in Neurodegenerative Diseases - 3SURE MINDFrom1 May 2022 → TodayFunding: FWO Large scale research infrastructure
- FB-III (“FB triple-I”) : Flanders BioImaging: Integrating Imaging Infrastructure from cell to man.From1 Feb 2021 → TodayFunding: FWO International research infrastructure (IRI)
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- Development of new chemical tools to investigate the role of L-type calcium channels in diseases.From6 Oct 2020 → TodayFunding: FWO Strategic Basic Research Grant
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Development of an interdisciplinary platform for spatial multi-omic analysis of single cellsFrom1 Oct 2019 → 30 Sep 2023Funding: BOF - projects
- Structural bases of γ-secretase processivity in Familial Alzheimer's DiseaseFrom1 Feb 2019 → 1 Feb 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
11 - 20 of 169
- The amyloid cascade hypothesis: are we poised for success or failure?(2016)
Authors: Eric Karran, Bart De Strooper
Pages: 237 - 252 - Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity(2017)
Authors: Rudi D'Hooge, Bart De Strooper, Carlos Dotti
Pages: 1 - 21 - A Physiological Study of the Amyloid Precursor Protein - A Stem Cell Based Approach(2009)
Authors: Bruno Bergmans, Bart De Strooper, Carlos Dotti
Number of pages: 97 - Alzheimer's dementia by circulation disorders: when trees hide the forest(2009)
Authors: Carlos Dotti, Bart De Strooper
Pages: 114 - 116 - Cholesterol loss during glutamate-mediated excitotoxicity(2012)
Authors: Debapriya Ghosh, Thomas Voets, Carlos Dotti
Pages: 1764 - 73 - LRRK2 Controls an EndoA Phosphorylation Cycle in Synaptic Endocytosis(2012)
Authors: Samer Matta, Kristof Van Kolen, Raquel da Cunha, Geert van den Bogaart, Wim Mandemakers, Katarzyna Miskiewicz, Pieter-Jan De Bock, Vanessa Morais, Sven Vilain, Dominik Haddad, et al.
Pages: 1008 - 1021 - Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease(2012)
Authors: Francesc Guix, Tina Wahle, Lucia Chavez Gutierrez, Carlos Dotti, Bart De Strooper
Pages: 660 - 673 - A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals(2016)
Authors: Sandra Fausia Soukup, Roeland Vanhauwaert, Julia Manetsberger, Sven Vilain, Natalia Gunko, Bart De Strooper, Patrik Verstreken
Pages: 829 - 844 - Cholesterol and Alzheimer's Disease: The Molecules, the Targets(2010)
Authors: Carlos Dotti
Pages: 38 - 58Number of pages: 21 - Visualization and quantification of the stromal-vascular compartment in fetal or adult mouse bones: from sampling to high-resolution 3D image analysis.(2022)
Authors: Nicolas Peredo, Roger Valle Tenney, Seppe Melis, Christa Maes