Organisation
Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven)
Division
The Lab of Molecular Oncology and Angiogenesis aims to shed light on the genetic and molecular mechanisms that regulate vessel shape remodeling and endothelial cell fate, with the overall aim of defining alternative therapeutic opportunities to improve anti-cancer therapy, as well as therapeutic angiogenesis for revascularization of ischemic tissues.
Current researchers
1 - 8 of 8 results
- Max Mazzone (Responsible)
- Emanuele Berardi (Member)
- Federica Cappellesso (Member)
- Marie-Pauline Orban (Member)
- Carla Riera Domingo (Member)
- Silvia Rivis (Member)
- Tommaso Scolaro (Member)
- Shikang Zhao (Member)
Projects
1 - 10 of 69
- Targeting the DNA methylation profile of cytotoxic T cells to overcome immunotherapy resistance of pancreatic cancerFrom5 Mar 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding glutamate metabolism in the tumor microenvironment to tackle Immune Checkpoint Blockade (ICB) resistanceFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Role of SLC1A3 in tumor-associated macrophages during immunotherapy resistance onset in breast cancerFrom1 Oct 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Targeting the CDA/P2Y6 axis to overcome immunosuppression and favor response to immune checkpoint inhibitors in pancreatic cancerFrom1 Jul 2023 → TodayFunding: Other federal public and semi-governmental institutions
- Tackling tumor immunosuppression by reprograming eicosanoid metabolism and signaling in the tumor microenvironmentFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Understanding the roles of the epigenetic machinery in shaping distinct tumor-associated macrophage phenotypes.From10 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Tackling SLC1A3 in tumor-associated macrophages to overcome anti-PD1 immunotherapy resistance in breast cancerFrom31 Oct 2022 → TodayFunding: FWO Strategic Basic Research Grant
- LipoMacs: functional Lipidomics to unlock Macrophage-mediated therapyFrom1 Oct 2022 → TodayFunding: FWO Strategic Basic Research (SBO)
- BD Imaging Cell Sorter – BD Cell View TechnologyTMFrom24 Jun 2022 → TodayFunding: Other federal scientific institutions
- Tricking tumor immunosuppression: RNA epigenetics as novel target to improve cancer immunotherapyFrom1 Jan 2022 → TodayFunding: FWO EOS
Publications
41 - 50 of 311
- HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF(2011)
Authors: Max Mazzone, Ellen Knevels, Uwe Himmelreich, Mieke Dewerchin, Peter Carmeliet
Pages: 31 - 44 - Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity(2017)
Authors: Andrea Casazza, Shehab Ismail Mohamed, Peter Carmeliet, Max Mazzone
Pages: 14206 - Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis(2012)
Authors: Peter Carmeliet, Max Mazzone
Pages: 1955 - 1965 - Bone marrow stromal cells from beta-thalassemia patients have impaired hematopoietic supportive capacity(2019)
Authors: Stefania Crippa, Valeria Rossella, Annamaria Aprile, Laura Silvestri, Silvia Rivis, Samantha Scaramuzza, Stefania Pirroni, Maria Antonietta Avanzini, Luca Basso-Ricci, Raisa Jofra Hernandez, et al.
Pages: 1566 - 1580 - Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited HSPCs(2021)
Authors: Silvia Rivis
Pages: A57 - A57 - The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts(2015)
Authors: Stijn Moens, Bert Cruys, Bernard Thienpont, Michaël Broux, Carmen Bartic, Diether Lambrechts, Mieke Dewerchin, Max Mazzone, Peter Carmeliet
Pages: 992 - 1005 - Impaired Autonomic Regulation of Resistance Arteries in Mice With Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery(2010)
Authors: Erik Storkebaum, Max Mazzone, Koen Poesen, Diether Lambrechts, Patrik Verstreken, Peter Carmeliet
Pages: 273 - 281 - Targeting Neuropilin-1 with Nanobodies Reduces Colorectal Carcinoma Development(2020)
Authors: Maarten Dewilde, Max Mazzone
- Cryptic transcripts: the masked heroes that break tumor immunotolerance and rescue the immunotherapy response(2021)
Authors: Laurien Van Dyck, Diether Lambrechts, Max Mazzone, Bernard Thienpont
- Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function(2021)
Authors: Max Mazzone
Pages: 1071 - 1090