Organisation
Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven)
Division
The Lab of Molecular Oncology and Angiogenesis aims to shed light on the genetic and molecular mechanisms that regulate vessel shape remodeling and endothelial cell fate, with the overall aim of defining alternative therapeutic opportunities to improve anti-cancer therapy, as well as therapeutic angiogenesis for revascularization of ischemic tissues.
Current researchers
1 - 7 of 7 results
- Max Mazzone (Responsible)
- Emanuele Berardi (Member)
- Marie-Pauline Orban (Member)
- Carla Riera Domingo (Member)
- Silvia Rivis (Member)
- Tommaso Scolaro (Member)
- Shikang Zhao (Member)
Projects
1 - 10 of 69
- Targeting the DNA methylation profile of cytotoxic T cells to overcome immunotherapy resistance of pancreatic cancerFrom5 Mar 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding glutamate metabolism in the tumor microenvironment to tackle Immune Checkpoint Blockade (ICB) resistanceFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Role of SLC1A3 in tumor-associated macrophages during immunotherapy resistance onset in breast cancerFrom1 Oct 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Targeting the CDA/P2Y6 axis to overcome immunosuppression and favor response to immune checkpoint inhibitors in pancreatic cancerFrom1 Jul 2023 → TodayFunding: Other federal public and semi-governmental institutions
- Tackling tumor immunosuppression by reprograming eicosanoid metabolism and signaling in the tumor microenvironmentFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Understanding the roles of the epigenetic machinery in shaping distinct tumor-associated macrophage phenotypes.From10 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Tackling SLC1A3 in tumor-associated macrophages to overcome anti-PD1 immunotherapy resistance in breast cancerFrom31 Oct 2022 → TodayFunding: FWO Strategic Basic Research Grant
- LipoMacs: functional Lipidomics to unlock Macrophage-mediated therapyFrom1 Oct 2022 → TodayFunding: FWO Strategic Basic Research (SBO)
- BD Imaging Cell Sorter – BD Cell View TechnologyTMFrom24 Jun 2022 → TodayFunding: Other federal scientific institutions
- Tricking tumor immunosuppression: RNA epigenetics as novel target to improve cancer immunotherapyFrom1 Jan 2022 → TodayFunding: FWO EOS
Publications
1 - 10 of 314
- Modulating chitosan-PLGA nanoparticle properties to design a co-delivery platform for glioblastoma therapy intended for nose-to-brain route(2020)
Authors: Natalia N Ferreira, Sara Granja, Fernanda Boni, Fabiola G Prezotti, Leonardo MB Ferreira, Beatriz SF Cury, Rui M Reis, Fatima Baltazar, Maria Palmira D Gremiao
Pages: 1729 - 1747 - Crosstalk between glial and glioblastoma cells triggers the "go-or-grow" phenotype of tumor cells(2017)
Authors: Ana Ferreira de Oliveira, Sandra I Anjo, Joana Vieira de Castro, Sofia C Serra, Antonio J Salgado, Bruno Manadas, Bruno M Costa
- PD-1/PD-L1 immune checkpoint inhibitors in neoadjuvant therapy for solid tumors (Review)(2023)
Authors: Shikang Zhao
- A NEW ROLE FOR MMP-10 IN PATIENTS WITH PERIPHERAL ARTERY DISEASE AND EXPERIMENTAL ARTERIAL ISCHEMIA(2014)
Authors: Max Mazzone
Pages: E161 - E161 - The impact of hypoxia on tumor-associated macrophages(2016)
Authors: Anne-Theres Henze, Max Mazzone
Pages: 3672 - 3679 - Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia (vol 12, 435, 2021)(2021)
Authors: Germana Zaccagnini, Simona Greco, Marialucia Longo, Biagina Maimone, Christine Voellenkle, Paola Fuschi, Matteo Carrara, Pasquale Creo, Davide Maselli, Mario Tirone, et al.
- Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability(2022)
Authors: Max Mazzone
- The anti-proliferative effect of L-carnosine correlates with a decreased expression of hypoxia inducible factor 1 alpha in human colon cancer cells(2014)
Authors: Max Mazzone
- Loss of Caveolin-1 in Metastasis-Associated Macrophages Drives Lung Metastatic Growth through Increased Angiogenesis(2017)
Authors: Ward Celus, Manuel Ehling, Max Mazzone
Pages: 2842 - 2854 - Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism?(2020)
Authors: Max Mazzone