Organisation
Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven)
Division
The Lab of Molecular Oncology and Angiogenesis aims to shed light on the genetic and molecular mechanisms that regulate vessel shape remodeling and endothelial cell fate, with the overall aim of defining alternative therapeutic opportunities to improve anti-cancer therapy, as well as therapeutic angiogenesis for revascularization of ischemic tissues.
Current researchers
1 - 8 of 8 results
- Max Mazzone (Responsible)
- Emanuele Berardi (Member)
- Federica Cappellesso (Member)
- Marie-Pauline Orban (Member)
- Carla Riera Domingo (Member)
- Silvia Rivis (Member)
- Tommaso Scolaro (Member)
- Shikang Zhao (Member)
Projects
1 - 10 of 69
- Targeting the DNA methylation profile of cytotoxic T cells to overcome immunotherapy resistance of pancreatic cancerFrom5 Mar 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding glutamate metabolism in the tumor microenvironment to tackle Immune Checkpoint Blockade (ICB) resistanceFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Role of SLC1A3 in tumor-associated macrophages during immunotherapy resistance onset in breast cancerFrom1 Oct 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Targeting the CDA/P2Y6 axis to overcome immunosuppression and favor response to immune checkpoint inhibitors in pancreatic cancerFrom1 Jul 2023 → TodayFunding: Other federal public and semi-governmental institutions
- Tackling tumor immunosuppression by reprograming eicosanoid metabolism and signaling in the tumor microenvironmentFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Understanding the roles of the epigenetic machinery in shaping distinct tumor-associated macrophage phenotypes.From10 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Tackling SLC1A3 in tumor-associated macrophages to overcome anti-PD1 immunotherapy resistance in breast cancerFrom31 Oct 2022 → TodayFunding: FWO Strategic Basic Research Grant
- LipoMacs: functional Lipidomics to unlock Macrophage-mediated therapyFrom1 Oct 2022 → TodayFunding: FWO Strategic Basic Research (SBO)
- BD Imaging Cell Sorter – BD Cell View TechnologyTMFrom24 Jun 2022 → TodayFunding: Other federal scientific institutions
- Tricking tumor immunosuppression: RNA epigenetics as novel target to improve cancer immunotherapyFrom1 Jan 2022 → TodayFunding: FWO EOS
Publications
31 - 40 of 311
- N-acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages(2021)
Authors: Max Mazzone
- piggyBac transposons expressing full-length human dystrophin enable genetic correction of dystrophic mesoangioblasts(2016)
Authors: Mariana Loperfido, Mario di Matteo, Ilaria Perini, Maurilio Sampaolesi, Thierry Vandendriessche, Marinee Chuah
Pages: 744 - 760 - Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice(2012)
Authors: Mario di Matteo, Marinee Chuah, Thierry Vandendriessche
Pages: 4517 - 4520 - Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation(2021)
Authors: Federico Virga, Federica Cappellesso, Rosa Trotta, Lies Langouche, Greet Van den Berghe, Max Mazzone
- Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons(2020)
Authors: Mario di Matteo
Pages: 1309 - 1329 - Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting(2013)
Authors: Max Mazzone, Peter Carmeliet
Pages: 607 - 617 - Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism(2017)
Authors: Max Mazzone, Jermaine Goveia, Federico Taverna, Peter Carmeliet
- Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury(2010)
Authors: Max Mazzone, Katrien De Bock, Maria Georgiadou, Myriam Baes, Peter Carmeliet
Pages: 1143 - Macrophage-derived glutamine boosts satellite cells and muscle regeneration(2020)
Authors: Federica Cappellesso, Federico Virga, Guy Eelen, Peter Carmeliet, Mario di Matteo, Emanuele Berardi, Max Mazzone
Pages: 626 - + - The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation (vol 5, pg 1523, 2013)(2014)
Authors: Rossella Luca, Michele Averna, Francesca Zalfa, Manuela Vecchi, Fabrizio Bianchi, Giorgio La Fata, Franca Del Nonno, Roberta Nardacci, Marco Bianchi, Paolo Nuciforo, et al.
Pages: 567 - 567