Organisation
Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven)
Division
The Lab of Molecular Oncology and Angiogenesis aims to shed light on the genetic and molecular mechanisms that regulate vessel shape remodeling and endothelial cell fate, with the overall aim of defining alternative therapeutic opportunities to improve anti-cancer therapy, as well as therapeutic angiogenesis for revascularization of ischemic tissues.
Current researchers
1 - 7 of 7 results
- Max Mazzone (Responsible)
- Emanuele Berardi (Member)
- Marie-Pauline Orban (Member)
- Carla Riera Domingo (Member)
- Silvia Rivis (Member)
- Tommaso Scolaro (Member)
- Shikang Zhao (Member)
Projects
1 - 10 of 68
- Targeting the DNA methylation profile of cytotoxic T cells to overcome immunotherapy resistance of pancreatic cancerFrom5 Mar 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding glutamate metabolism in the tumor microenvironment to tackle Immune Checkpoint Blockade (ICB) resistanceFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Role of SLC1A3 in tumor-associated macrophages during immunotherapy resistance onset in breast cancerFrom1 Oct 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Targeting the CDA/P2Y6 axis to overcome immunosuppression and favor response to immune checkpoint inhibitors in pancreatic cancerFrom1 Jul 2023 → TodayFunding: Other federal public and semi-governmental institutions
- Tackling tumor immunosuppression by reprograming eicosanoid metabolism and signaling in the tumor microenvironmentFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Tackling SLC1A3 in tumor-associated macrophages to overcome anti-PD1 immunotherapy resistance in breast cancerFrom31 Oct 2022 → TodayFunding: FWO Strategic Basic Research Grant
- LipoMacs: functional Lipidomics to unlock Macrophage-mediated therapyFrom1 Oct 2022 → TodayFunding: FWO Strategic Basic Research (SBO)
- BD Imaging Cell Sorter – BD Cell View TechnologyTMFrom24 Jun 2022 → TodayFunding: Other federal scientific institutions
- Tricking tumor immunosuppression: RNA epigenetics as novel target to improve cancer immunotherapyFrom1 Jan 2022 → TodayFunding: FWO EOS
- Duchenne muscular dystrophy.From1 Jan 2022 → 31 Dec 2022Funding: Nonprofit institution or equivalents
Publications
21 - 30 of 314
- Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization(2009)
Authors: Max Mazzone, Rodrigo Leite-de-Oliveira, Frederik De Smet, Koen Debackere, Aernout Luttun, Peter Carmeliet
Pages: 839 - 851 - Liver-Specific Transcriptional Modules Identified by Genome-Wide In Silico Analysis Enable Efficient Gene Therapy in Mice and Non-Human Primates(2014)
Authors: Marinee Chuah, Mario di Matteo, Bing Yan, Thierry Vandendriessche
Pages: 1605 - 1613 - Vessel Normalization in the Spot-LIGHT of Cancer Treatment(2016)
Authors: Manuel Ehling, Max Mazzone
Pages: 85 - 7 - Betulinic Acid Hydroxamate is Neuroprotective and Induces Protein Phosphatase 2A-Dependent HIF-1α Stabilization and Post-transcriptional Dephosphorylation of Prolyl Hydrolase 2(2021)
Authors: Max Mazzone
Pages: 1849 - 1861 - Systemic and Targeted Delivery of Semaphorin 3A Inhibits Tumor Angiogenesis and Progression in Mouse Tumor Models(2011)
Authors: Max Mazzone, Peter Carmeliet
Pages: 741 - Regulation of Angiogenesis by Oxygen and Metabolism(2009)
Authors: Max Mazzone, Peter Carmeliet
Pages: 167 - 179 - Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.(2010)
Authors: Frederik De Smet, Wouter Vandevelde, Max Mazzone, Annelii Ny, Peter Carmeliet, Mieke Dewerchin
Pages: 1695 - 1702 - Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses(2017)
Authors: Pranvera Sadiku, Joseph A Willson, Rebecca S Dickinson, Fiona Murphy, Alison J Harris, Amy Lewis, David Sammut, Ananda S Mirchandani, Eilise Ryan, Emily R Watts, et al.
Pages: 3407 - 3420 - Specific inhibition of the VEGF homolog placental growth factor is protective against osteolytic bone metastasis in mice(2010)
Authors: Lieve Coenegrachts, Christa Maes, Sophie Torrekens, Riet Van Looveren, Max Mazzone, Theresa A Guise, Roger Bouillon, Peter Carmeliet, Geert Carmeliet
Pages: S54 - S54 - Mesenchymal Stromal Cell support to optimize HSPC-Gene Editing(2019)
Authors: Silvia Rivis
Pages: A185 - A185