Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Current researchers
1 - 8 of 8 results
- Diether Lambrechts (Responsible)
- Ayse Bassez (Member)
- Dóra Bihary (Member)
- Diether Lambrechts (Member)
- Aurelie Mechels (Member)
- Junbin Qian (Member)
- Pierre Van Mol (Member)
- Sam Vanmassenhove (Member)
Projects
1 - 10 of 71
- Liquid biopsy and HRD testing in ovarian cancerFrom4 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Decoding the penile cancer tumor microenvironment: heterogeneity of tumor-associated epithelial cell states, it's relationship with HPV, and it's role in prognosis and therapy response.From1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integration of Spatial Transcript- and Proteomics Techniques with Pan-cancer single cell RNA-sequencing data to interrogate the impact of immunotherapy on the Tumor Microenvironment (TME)From9 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An Integrated Spatial Atlas of the Tumor Micro-environment of Early Non-Small Cell Lung CancerFrom16 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Abemaciclib and letrozole in ER positive rare ovarian cancerFrom1 Mar 2023 → TodayFunding: Foundations, funds and other with scientific goal
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
- Refining the role of dual checkpoint inhibition in advanced lung cancer: a single-cell approachFrom5 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Multiomic Integration of cell-free DNA profiles to Advance Disease OutcomeFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Connecting Single-cell Immune Profiling in Peripheral Blood with Intratumoral T Cell Expansion in Breast Cancer Upon Checkpoint ImmunotherapyFrom24 Aug 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs).From9 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
551 - 560 of 664
- Genetic Variation in Immunoglobulin G Receptor Affects Survival After Lung Transplantation(2014)
Authors: David Ruttens, Stijn Verleden, P Goeminne, Elly Vandermeulen, Els Wauters, Robin Vos, Dirk Van Raemdonck, Diether Lambrechts, Bart Vanaudenaerde, Geert Verleden
Pages: S30 - S30 - c-MET/VEGFR-2 co-localisation impacts on survival following bevacizumab therapy in epithelial ovarian cancer: an exploratory biomarker study of the phase 3 ICON7 trial(2022)
Authors: Diether Lambrechts
- Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC)(2015)
Authors: Evelyn Despierre, Diether Lambrechts, Sandrina Lambrechts, Ignace Vergote
Pages: 017 - Identification of genetic risk factors associated with idiopathic achalasia by a genetic candidate study(2012)
Authors: Mira Wouters, Diether Lambrechts, Isabelle Cleynen, I Gockel, Jan Hendrik Becker, Jan Tack, A Vigo, A Ruiz De Leon, J Perez De La Serna, W Rohof, et al.
Pages: 25 - 25 - Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk(2015)
Authors: Evelyn Despierre, Diether Lambrechts, Sandrina Lambrechts, Ignace Vergote
Pages: 689 - 97 - FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium(2014)
Authors: Diether Lambrechts, Beppe Floris, Karin Leunen
Pages: 1088 - 100 - Establishment of preclinical endometrial carcinoma models and evaluation of new treatment options(2015)
Authors: Stefanie Schrauwen, Frédéric Amant, Diether Lambrechts
Number of pages: 153 - Age-related changes in DNA methylation affect renal histology and post-transplant fibrosis(2019)
Authors: Line Heylen, Bernard Thienpont, Pieter Busschaert, Ben Sprangers, Dirk Kuypers, Matthieu Moisse, Diether Lambrechts, Maarten Naesens
Pages: 1195 - 1204 - It's T Time for Normal Blood Vessels(2017)
Authors: Bernard Thienpont, Diether Lambrechts
Pages: 125 - 126 - Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus(2019)
Authors: Diether Lambrechts, Ignace Vergote
Pages: 467 - 481