Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Current researchers
1 - 8 of 8 results
- Diether Lambrechts (Responsible)
- Ayse Bassez (Member)
- Dóra Bihary (Member)
- Diether Lambrechts (Member)
- Aurelie Mechels (Member)
- Junbin Qian (Member)
- Pierre Van Mol (Member)
- Sam Vanmassenhove (Member)
Projects
1 - 10 of 71
- Liquid biopsy and HRD testing in ovarian cancerFrom4 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Decoding the penile cancer tumor microenvironment: heterogeneity of tumor-associated epithelial cell states, it's relationship with HPV, and it's role in prognosis and therapy response.From1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integration of Spatial Transcript- and Proteomics Techniques with Pan-cancer single cell RNA-sequencing data to interrogate the impact of immunotherapy on the Tumor Microenvironment (TME)From9 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An Integrated Spatial Atlas of the Tumor Micro-environment of Early Non-Small Cell Lung CancerFrom16 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Abemaciclib and letrozole in ER positive rare ovarian cancerFrom1 Mar 2023 → TodayFunding: Foundations, funds and other with scientific goal
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
- Refining the role of dual checkpoint inhibition in advanced lung cancer: a single-cell approachFrom5 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Multiomic Integration of cell-free DNA profiles to Advance Disease OutcomeFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Connecting Single-cell Immune Profiling in Peripheral Blood with Intratumoral T Cell Expansion in Breast Cancer Upon Checkpoint ImmunotherapyFrom24 Aug 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs).From9 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
501 - 510 of 664
- Metabolomic and transcriptomic response to imatinib treatment of gastrointestinal stromal tumour in xenograft-bearing mice.(2023)
Authors: Diether Lambrechts, Bram Boeckx, Agnieszka Wozniak, Patrick Schöffski
Pages: 101632 - Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals(2017)
Authors: Bram Boeckx, Diether Lambrechts
Pages: 313 - 322 - GLI2 promoter hypermethylation in saliva of children with a respiratory allergy(2018)
Authors: Matthieu Moisse, Guy Van Camp, Diether Lambrechts
- Lineage-specific functions of TET1 in the postimplantation mouse embryo(2017)
Authors: Rita Khoueiry, Bernard Thienpont, Xinlong Luo, Michela Bartoccetti, Bram Boeckx, An Zwijsen, Diether Lambrechts, Kian Koh
Pages: 1061 - + - Vitamin D supplementation in cutaneous malignant melanoma outcome (ViDMe): a randomized controlled trial(2017)
Authors: Veerle Boecxstaens, Marguerite Stas, Kris Bogaerts, Dirk Vanderschueren, Katleen Vandenberghe, Diether Lambrechts, Oliver Bechter, Vivien Marasigan, Maria Garmyn
Pages: 562 - Organoids from human tooth showing epithelial stemness phenotype and differentiation potential(2022)
Authors: Lara Hemeryck, Florian Hermans, Diether Lambrechts, Hugo Vankelecom
- ESTABLISHING A CLINICALLY RELEVANT MOUSE MODEL OF MESENCHYMAL GLIOBLASTOMA FOR STUDYING TME TARGETING TREATMENTS.(2023)
Authors: Ingrid Arijs, Diether Lambrechts, Frederik De Smet
- Ischemia in kidney transplantation: clinical risk factor and epigenetic modifier(2017)
Authors: Line Heylen, Ben Sprangers, Diether Lambrechts, Maarten Naesens
- Genomic Characterization of Primary Invasive Lobular Breast Cancer(2016)
Authors: Christine Desmedt, Peter Van Loo, Diether Lambrechts
Pages: 1872 - + - Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19(2022)
Authors: Caroline Martens, Pierre Van Mol, Joost Wauters, Els Wauters, Laurens Liesenborghs, Elisabeth Heylen, Sander Jansen, Sirima Kraisin, Robin Vos, Christophe Vandenbriele, et al.