Laboratory for Mechanisms of Cell Transformation (VIB-KU Leuven)

The research interests from the Laboratory for Mechanisms of Cell Transformation are focused on understanding the cooperative interactions that conspire to promote tumorigenic transformation. To discover drivers of cancer development and progression, they create experimental models of cell transformation derived from primary human cells that mimic alterations found in human cancer samples. These models provide a useful platform to delineate pathways involved in cell transformation and to discover new targets for therapeutic intervention. In particular, they are pursuing two research directions:

• Post-translational modification of the RAS-like GTPase 
• The role of large chromosomal deletions in cancer development and progression