Organisation
Laboratory for Disease Mechanisms in Cancer
Division
The Laboratory for Disease Mechanisms in Cancer conducts research into the link between the ribosome and cancer. The research questionson wich the laboratory focuses are:
1) What is the spectrum of acquired ribosome defects in cancer?
2) By what mechanisms do ribosome defects promote cancer?
3) Are ribosome defects therapeutically relevant?
Current researchers
1 - 10 of 10 results
- Kim De Keersmaecker (Responsible)
- Marino Caruso (Member)
- Kim De Keersmaecker (Member)
- Elien Heylen (Member)
- Xander Janssens (Member)
- Kim Kampen (Member)
- Grecia Marron Linares (Member)
- Linde Van Aerschot (Member)
- Benno Verbelen (Member)
- Paulien Verstraete (Member)
Projects
1 - 10 of 44
- Raising the voice of silent mutations in cancerFrom1 Oct 2023 → TodayFunding: BOF - postdoctoral mandates
- Deregulated mRNA transcription and protein translation in the transformation of normal T-cells to malignant cells.From1 Jan 2023 → TodayFunding: BOF - iBOF
- Serine/glycine synthesis addiction in acute lymphoblastic leukemia and resulting therapeutic opportunitiesFrom4 Jul 2021 → TodayFunding: FWO fellowships
- Serine/glycine synthesis addiction in acute lymphoblastic leukemia and resulting therapeutic opportunitiesFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- VyCAP single cell isolation platform for high-quality single-cell analysisFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- Role of -1 programmed ribosomal frameshifting dysregulation on the JAK2 oncogeneFrom25 Jul 2020 → TodayFunding: FWO fellowships
- Silent mutations in cancerFrom1 May 2020 → TodayFunding: H2020 - Frontier Research (ERC)
- The role of NKX2-1 in T-cell acute lymphoblastic leukemia and NKX2-1 cooperation with the ribosomal RPL10 R98S and NOTCH1 mutations.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Role of PTEN dysregulation downstream of ribosomal protein RPL5/RPL11 lesions in cancer.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Fidelity of translation in healthy agingFrom26 Sep 2019 → 26 Sep 2023Funding: BOF - doctoral mandates
Publications
31 - 40 of 108
- A structural equation model to assess the pathways of body adiposity and inflammation status on dysmetabolic biomarkers via red cell distribution width and mean corpuscular volume: a cross-sectional study in overweight and obese subjects(2020)
Authors: Daniele Pepe
- Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia(2013)
Authors: Kim De Keersmaecker, Zeynep Kalender Atak, Carmen Vicente, Tiziana Girardi, Ellen Geerdens, Michaël Porcu, Barbara Cauwelier, Anne Uyttebroeck, Claudia Bagni, Bassem Hassan, et al.
Pages: 186 - 190 - Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia(2009)
Authors: Ria Kleppe, Idoya Lahortiga, Tiama El Chaar, Kim De Keersmaecker, Nicole Mentens, Carlos Graux, Katrien Van Roosbroeck, Adolfo A Ferrando, Anton W Langerak, Jules PP Meijerinck, et al.
Pages: 65 - 65 - The genetics and molecular biology of T-ALL(2017)
Authors: Tiziana Girardi, Carmen Vicente, Jan Cools, Kim De Keersmaecker
Pages: 1113 - 1123 - The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL(2018)
Authors: Kim Kampen, Sergey Sulima, Benno Verbelen, Tiziana Girardi, Stijn Vereecke, Gianmarco Rinaldi, Anne Uyttebroeck, Jan Cools, David Cassiman, Sarah-Maria Fendt, et al.
Pages: 319 - 332 - In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia(2008)
Authors: Kim De Keersmaecker, Peter Vandenberghe, Peter Marynen, Jan Cools
Pages: 533 - 542 - Optimizing the diagnostic workflow for acute lymphoblastic leukemia by optical genome mapping(2022)
Authors: Jolien De Bie, Sofie Demeyer, Jan Cools, Kim De Keersmaecker, Joris Vermeesch, Johan Maertens, Heidi Segers, Lucienne Michaux, Barbara Dewaele
Pages: 548 - 561 - Ruxolitinib Synergizes With Dexamethasone for the Treatment of T-cell Acute Lymphoblastic Leukemia(2019)
Authors: Delphine Verbeke, Nancy Boeckx, Kim De Keersmaecker, Johan Maertens, Anne Uyttebroeck, Heidi Segers, Jan Cools
- Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases(2008)
Authors: Kim De Keersmaecker, Jan Cools
Pages: 2208 - 2216 - Bloody Mysteries of Ribosomes(2018)
Authors: Kim De Keersmaecker