Organisation
Laboratory of Computational Biology (VIB-KU Leuven)
Division
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
Projects
41 - 50 of 64
- Unravelling Single Cell Gene Regulatory Networks in DrosophilaFrom10 May 2017 → 30 Sep 2018Funding: Own budget, for example: patrimony, inscription fees, gifts
- Deciphering the genetic program of epithelial cellsFrom1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- Deciphering the regulatory code underlying a common epigenomic survival switch in cancerFrom1 Jan 2017 → 31 Dec 2020Funding: Foundations, funds and other with scientific goal
- Exploiting enhancer logic and transcriptional networks to control phenotype switching in melanomaFrom1 Oct 2016 → 14 Dec 2020Funding: FWO Strategic Basic Research Grant, Private funding of national origin - undefined
- Towards petascale biocomputational sciencesFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- Regulatory genomics of normal cell differentiation and cancer cell subpopulations in the same tissue of origin.From1 Oct 2014 → 11 Jun 2021Funding: IWT personal funding - strategic basic research grants
- Drosophila Allograft Screen to Identify cis-Regulatory Variation in Cancer Genomes.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Using photoreceptor differentiation in Drosophila as a model system in order to decipher how a developmental program is encoded in a metazoan genome.From1 Oct 2013 → 30 Sep 2017Funding: BOF - Concerted Research Project from 1994
- Drosophila allograft screen to identify cis-regulatory variation in cancer genomes.From1 Oct 2013 → 9 May 2018Funding: IWT personal funding - strategic basic research grants
- Identification of cancer driver mutations in the non-coding genome by integrative genomics and regulome sequencing.From1 Jan 2013 → 31 Dec 2016Funding: Private funding of national origin - undefined
Publications
1 - 10 of 177
- A pan-cancer landscape of somatic mutations in non-unique regions of the human genome(2021)
Authors: Jonas Demeulemeester, Annelien Verfaillie
Pages: 1589 - + - In search of cancer stem cells in cutaneous melanoma.(2012)
Authors: Jasper Wouters, Hugo Vankelecom, Joost van den Oord
Number of pages: 206 - SIDE POPULATION ANALYSIS IDENTIFIES A ROLE FOR LAMININ IN MODULATING THE HUMAN HEPATIC CANCER STEM CELL NICHE(2014)
Authors: Olivier Govaere, Jasper Wouters, M Petz, Kathleen Van den Eynde, A Van den Broeck, C Empsen, L Gremeaux, An Ceulemans, R Aerts, Frederik Nevens, et al.
Pages: S92 - S92 - Gene expression changes in melanoma metastases in response to high-dose chemotherapy during isolated limb perfusion(2012)
Authors: Jasper Wouters, Marguerite Stas, Olivier Govaere, Hugo Vankelecom, Joost van den Oord
Pages: 454 - 465 - Convergent and lineage-specific genomic differences in limb regulatory elements in limbless reptile lineages(2022)
Authors: Nikolai Hecker
- Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma(2020)
Authors: Jasper Wouters, Liesbeth Minnoye, Katina Spanier, David Mauduit, Kristofer Davie, Michael Dewaele, Dennis Pedri, Frederik Ceyssens, Chris Marine, Stein Aerts
Pages: 986 - + - microRNA-132 regulates gene expression programs involved in microglial homeostasis(2023)
Authors: Kristofer Davie, Nicky Thrupp, Mark Fiers, Bart De Strooper
- Interpretation of allele-specific chromatin accessibility using cell state-aware deep learning(2021)
Authors: Ibrahim Ihsan Taskiran, Jonas Demeulemeester, David Mauduit, Valerie Christiaens, Jasper Wouters, Stein Aerts
- Genome-wide analyses of Shavenbaby target genes reveals distinct features of enhancer organization(2013)
Authors: Stein Aerts
- TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophila(2013)
Authors: Lies Vanden Broeck, Marc Gistelinck, Stein Aerts, Patrick Callaerts
Pages: 160 - 172