Organisation
Laboratory of Computational Biology (VIB-KU Leuven)
Division
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
Current researchers
1 - 10 of 21 results
- Stein Aerts (Responsible)
- Darina Abaffyová (Member)
- Stein Aerts (Member)
- Sara Aibar Santos (Member)
- Cas Blaauw (Member)
- Carmen Bravo González-Blas (Member)
- Florian De Rop (Member)
- Seppe De Winter (Member)
- Hannah Dickmänken (Member)
- Sam Dieltiens (Member)
Projects
1 - 10 of 64
- Understanding gene regulation in a whole animal: From building a regulatory atlas to decoding gene regulation with deep learningFrom10 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SpaceTimeOmics: combining high-throughput spatial omics with AI to model gene regulation in space and timeFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Interpretation of genomic regulatory variation in the human brain and Parkinson’s Disease by integrating deep learning with single-cell multi-omicsFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Deep learning based synthetic design and massively parallel reporter assays to characterize and exploit cell type specific enhancersFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Enhancer-AI: AI-driven modelling and design of cell type specific enhancers for gene therapyFrom1 Oct 2023 → TodayFunding: FWO Strategic Basic Research (SBO)
- Deep learning solutions for deciphering gene regulation in the human brainFrom7 Mar 2023 → TodayFunding: FWO Strategic Basic Research Grant
- The role of smORF encoded polypeptides in lager beer fermentationFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Applications of deep learning for cancer genomicsFrom1 Jan 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Evolution of the genomic regulatory code underlying neuronal diversityFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
Publications
1 - 10 of 177
- Mass Spectrometry of Flame Figures(2015)
Authors: Jasper Wouters, Etienne Waelkens, Siegfried Segaert, Joost van den Oord
Pages: 734 - 735 - First-in-Human Proof-of-Concept Study: Intralesional Administration of BQ788, an Endothelin Receptor B Antagonist, to Melanoma Skin Metastases(2015)
Authors: Jasper Wouters, Joost van den Oord
Pages: 1121 - 1122 - Prognostic and predictive biomarkers in melanoma: an update(2016)
Authors: Jasper Wouters
Pages: 223 - 237 - Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche(2016)
Authors: Olivier Govaere, Jasper Wouters, An Ceulemans, Frederik Nevens, Baki Topal, Hugo Vankelecom, Tania Roskams
Pages: 609 - 17 - KERATIN 19: A KEY ROLE PLAYER IN THE INVASION OF HUMAN HEPATOCELLULAR CARCINOMAS(2013)
Authors: Olivier Govaere, MIna Komuta, Joost Berkers, B Spee, Carl Janssen, F de Luca, A Katoonizadeh, Jasper Wouters, LC van Kempen, A Durnez, et al.
Pages: S430 - S430 - Keratin 19: a key role player in the invasion of human hepatocellular carcinomas(2014)
Authors: Olivier Govaere, MIna Komuta, Joost Berkers, Bart Spee, Carl Janssen, Francesca de Luca, Aezam Katoonizadeh, Jasper Wouters, Léon C van Kempen, Anne Durnez, et al.
Pages: 674 - 685 - Human pancreatic cancer contains a side population expressing cancer stem cell-associated and prognostic genes(2013)
Authors: Hugo Vankelecom, Wouter Van Delm, Jasper Wouters, Olivier Govaere, Tania Roskams, Baki Topal
- Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease(2022)
Authors: Olivier Govaere, Jasper Wouters, Matthias Van Haele, Baki Topal, Tania Roskams
Pages: 1001 - 1012 - A novel hypoxia-associated subset of FN1(high)MITF(low) melanoma cells: identification, characterization, and prognostic value(2014)
Authors: Jasper Wouters, Marguerite Stas, Olivier Govaere, Kathleen Barrette, Hugo Vankelecom, Joost van den Oord
Pages: 1088 - 1100 - Vision-related convergent gene losses reveal SERPINE3's unknown role in the eye(2022)
Authors: Nikolai Hecker