Organisation
Laboratory of Biosignaling & Therapeutics
Division
The Laboratory of Biosignaling & Therapeutics investigate cellular signal transduction pathways at the molecular level. One of our major goals is to identify and develop novel biomarkers or therapeutic targets for human diseases. The current focus is on the (mis)regulation of chromatin signaling, DNA repair and cell division in cancer cells by enzymes known as protein phosphatases.
Current researchers
1 - 10 of 11 results
- Mathieu Bollen (Responsible)
- Joao Barbosa (Member)
- Monique Beullens (Member)
- Mathieu Bollen (Member)
- Xinyu Cao (Member)
- Zander Claes (Member)
- Monica Dos Santos Ferreira (Member)
- Marloes Jonkhout (Member)
- Sarah Lemaire (Member)
- Aleyde Van Eynde (Member)
Projects
1 - 10 of 41
- Phospho-regulation at the crossroads of cell proliferation and DNA-damage controlFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Coordination of cell-cycle progression and DNA-damage repair by the protein phosphatase-1 regulator NIPP1From1 Mar 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Life-course regulators of protein phosphatase-1From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Host cell phosphatases in the life cycle of DNA virusesFrom1 Oct 2020 → TodayFunding: BOF - projects
- Dual function of SDS22 in the biogenesis of protein phosphatase-1 holoenzymesFrom14 Oct 2019 → 14 Oct 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of histone modifications in the life cycle of AAV2 and recombinant AAV-mediated transgene expressionFrom1 Oct 2019 → 27 Jan 2023Funding: FWO Strategic Basic Research Grant, BOF - doctoral mandates
- Chaperone-mediated biogenesis and activity regulation of protein phosphatase-1From3 Sep 2019 → 10 Jan 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Foundations, funds and other with scientific goal
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular timers of the spindle assembly checkpointFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
Publications
41 - 50 of 135
- The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme(2012)
Authors: Ewald Heroes, Monique Beullens, Mathieu Bollen
Pages: 1746 - 1756 - C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1(2012)
Authors: Monique Beullens, Mathieu Bollen
Pages: 4025 - 4039 - Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1(2014)
Authors: Monique Beullens, Mathieu Bollen
Pages: 2704 - 20 - The deletion of the phosphatase regulator NIPP1 causes progenitor cell expansion in the adult liver(2016)
Authors: Shannah Boens, Iris Verbinnen, Stefaan Verhulst, Kathelijne Szekér, Monica Ferreira, Thomas Gevaert, Myriam Baes, Tania Roskams, Leo A van Grunsven, Aleyde Van Eynde, et al.
- Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections(2024)
Authors: Mathieu Bollen
- Biochemical characterization of malate synthase G of P. aeruginosa(2009)
Authors: Bart Roucourt, Nikki Minnebo, Patrick Augustijns, Guido Volckaert, Rob Lavigne
Pages: 1 - 7 - Biochemical characterization of malate synthase G of P. aeruginosa(2009)
Authors: Bart Roucourt, Nikki Minnebo, Patrick Augustijns, Kirsten Hertveldt, Guido Volckaert, Rob Lavigne
Pages: 1 - 7 - Identification of protein phosphatase 1 as a regulator of the phosphorylation of LRRK2 in cells(2012)
Authors: Evy Lobbestael, Monique Beullens, Mathieu Bollen, Veerle Baekelandt, Jean-Marc Taymans
Pages: 119 - 128 - Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2 (vol 381, pg 71, 2004)(2017)
Authors: Anisoara Cimpean, Cristiana Stefan, Rik Gijsbers, Willy Stalmans, Mathieu Bollen
Pages: 4273 - 4274 - The phosphatase regulator NIPP1 restrains chemokine-driven skin inflammation.(2020)
Authors: Iris Verbinnen, Marloes Jonkhout, Kathelijne Szekér, Margareta Nikolic, Susan Schlenner, Aleyde Van Eynde, Mathieu Bollen
Pages: 1576 - 1588