Organisation
Laboratory of Biosignaling & Therapeutics
Division
The Laboratory of Biosignaling & Therapeutics investigate cellular signal transduction pathways at the molecular level. One of our major goals is to identify and develop novel biomarkers or therapeutic targets for human diseases. The current focus is on the (mis)regulation of chromatin signaling, DNA repair and cell division in cancer cells by enzymes known as protein phosphatases.
Current researchers
1 - 10 of 11 results
- Mathieu Bollen (Responsible)
- Joao Barbosa (Member)
- Monique Beullens (Member)
- Mathieu Bollen (Member)
- Xinyu Cao (Member)
- Zander Claes (Member)
- Monica Dos Santos Ferreira (Member)
- Marloes Jonkhout (Member)
- Sarah Lemaire (Member)
- Aleyde Van Eynde (Member)
Projects
1 - 10 of 41
- Phospho-regulation at the crossroads of cell proliferation and DNA-damage controlFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Coordination of cell-cycle progression and DNA-damage repair by the protein phosphatase-1 regulator NIPP1From1 Mar 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Life-course regulators of protein phosphatase-1From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Host cell phosphatases in the life cycle of DNA virusesFrom1 Oct 2020 → TodayFunding: BOF - projects
- Dual function of SDS22 in the biogenesis of protein phosphatase-1 holoenzymesFrom14 Oct 2019 → 14 Oct 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of histone modifications in the life cycle of AAV2 and recombinant AAV-mediated transgene expressionFrom1 Oct 2019 → 27 Jan 2023Funding: FWO Strategic Basic Research Grant, BOF - doctoral mandates
- Chaperone-mediated biogenesis and activity regulation of protein phosphatase-1From3 Sep 2019 → 10 Jan 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Foundations, funds and other with scientific goal
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular timers of the spindle assembly checkpointFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
Publications
31 - 40 of 135
- Physicians' attitudes and knowledge concerning antibiotic prescription and resistance: questionnaire development and reliability(2016)
Authors: Monica Dos Santos Ferreira
- Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells (Retraction of Vol 288, Pg 24200, 2013)(2017)
Authors: Cenk Kig, Monique Beullens, Lijs Beke, Aleyde Van Eynde, Johannes T Linders, Dirk Brehmer, Mathieu Bollen
Pages: 12786 - 12786 - Nature of the nuclear inclusions formed by PQBP1, a protein linked to neurodegenerative polyglutamine diseases(2008)
Authors: Emilia Nicolaescu, Monique Beullens, Bart Lesage, Stefaan Keppens, Bernard Himpens, Mathieu Bollen
Pages: 817 - 829 - Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the survival of motoneuron (SMN) pre-mRNA(2011)
Authors: Mathieu Bollen, Monique Beullens
Pages: 10126 - 10136 - Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing(2008)
Authors: Mathieu Bollen
Pages: 52 - 70 - CDK2 Regulates HIV-1 Transcription by Phosphorylation of CDK9 on Serine 90(2012)
Authors: Monique Beullens, Mathieu Bollen
Pages: 94 - Biogenesis and activity regulation of protein phosphatase 1(2017)
Authors: Iris Verbinnen, Mathieu Bollen
Pages: 89 - 99 - An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint(2017)
Authors: Junbin Qian, Monique Beullens, Maria Giulia Manzione, Lendert Gelens, Mathieu Bollen
Pages: 715 - 730 - The Importance of Kinase–Phosphatase Integration: Lessons from Mitosis(2018)
Authors: Lendert Gelens, Junbin Qian, Mathieu Bollen
Pages: 6 - 21 - Challenges and Opportunities in the Development of Protein Phosphatase-Directed Therapeutics(2013)
Authors: Sofie De Munter, Mathieu Bollen
Pages: 36 - 45