Organisation
Laboratory of Biosignaling & Therapeutics
Division
The Laboratory of Biosignaling & Therapeutics investigate cellular signal transduction pathways at the molecular level. One of our major goals is to identify and develop novel biomarkers or therapeutic targets for human diseases. The current focus is on the (mis)regulation of chromatin signaling, DNA repair and cell division in cancer cells by enzymes known as protein phosphatases.
Current researchers
1 - 10 of 11 results
- Mathieu Bollen (Responsible)
- Joao Barbosa (Member)
- Monique Beullens (Member)
- Mathieu Bollen (Member)
- Xinyu Cao (Member)
- Zander Claes (Member)
- Monica Dos Santos Ferreira (Member)
- Marloes Jonkhout (Member)
- Sarah Lemaire (Member)
- Aleyde Van Eynde (Member)
Projects
1 - 10 of 41
- Phospho-regulation at the crossroads of cell proliferation and DNA-damage controlFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Coordination of cell-cycle progression and DNA-damage repair by the protein phosphatase-1 regulator NIPP1From1 Mar 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Life-course regulators of protein phosphatase-1From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Host cell phosphatases in the life cycle of DNA virusesFrom1 Oct 2020 → TodayFunding: BOF - projects
- Dual function of SDS22 in the biogenesis of protein phosphatase-1 holoenzymesFrom14 Oct 2019 → 14 Oct 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of histone modifications in the life cycle of AAV2 and recombinant AAV-mediated transgene expressionFrom1 Oct 2019 → 27 Jan 2023Funding: FWO Strategic Basic Research Grant, BOF - doctoral mandates
- Chaperone-mediated biogenesis and activity regulation of protein phosphatase-1From3 Sep 2019 → 10 Jan 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Foundations, funds and other with scientific goal
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular timers of the spindle assembly checkpointFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
Publications
101 - 110 of 135
- Reply to Kaminski, NE; Cohen, SM Comment on "Bischoff et al. The Effects of the Food Additive Titanium Dioxide (E171) on Tumor Formation and Gene Expression in the Colon of a Transgenic Mouse Model for Colorectal Cancer. Nanomaterials 2022, 12, 1256"(2023)
Authors: Marloes Jonkhout
- Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis(2016)
Authors: Natalie De Geest, Rob van der Kant, Joost Schymkowitz, Frederic Rousseau, Mathieu Bollen, Monique Beullens, Pierre Vanderhaeghen, Bassem Hassan
Pages: 460 - 475 - Protein phosphatase 1: life-course regulation by SDS22 and Inhibitor-3(2022)
Authors: Xinyu Cao, Sarah Lemaire, Mathieu Bollen
Pages: 3072 - 3085 - Methylation of PITX2, HOXD3, RASSF1 and TDRD1 predicts biochemical recurrence in high-risk prostate cancer(2014)
Authors: Steven Joniau, Evelyne Lerut, Annouschka Laenen, Olivier Gevaert, Karin Haustermans, Monique Beullens, Aleyde Van Eynde, Mathieu Bollen
Pages: 1849 - 61 - A key function for the PP1 interactor NIPP1 in cancer cell proliferation and gene expression(2012)
Authors: Nele Van Dessel, Aleyde Van Eynde, Mathieu Bollen
Number of pages: 138 - Neural stem cells: the need for a proper orientation(2010)
Authors: Bart Lesage
Pages: 438 - 442 - Biogenesis and activity regulation of protein phosphatase 1 (vol 45, pg 89, 2017)(2017)
Authors: Iris Verbinnen, Monica Ferreira, Mathieu Bollen
Pages: 583 - 584 - Regulation of the protein phosphatase scaffold RepoMan during the cell cycle(2020)
Authors: Maria Giulia Manzione, Mathieu Bollen, Junbin Qian
- The role of RepoMan in chromosome-dependent microtubule nucleation(2017)
Authors: Sofie De Munter, Monique Beullens, Mathieu Bollen
Pages: 181 - 181 - On the detection of newer Epo forms in serum and urine using isoelectric focusing(2008)
Authors: Mathieu Bollen, Monique Beullens
Pages: 754 - 755