Organisation
Laboratory of Biosignaling & Therapeutics
Division
The Laboratory of Biosignaling & Therapeutics investigate cellular signal transduction pathways at the molecular level. One of our major goals is to identify and develop novel biomarkers or therapeutic targets for human diseases. The current focus is on the (mis)regulation of chromatin signaling, DNA repair and cell division in cancer cells by enzymes known as protein phosphatases.
Current researchers
1 - 10 of 11 results
- Mathieu Bollen (Responsible)
- Joao Barbosa (Member)
- Monique Beullens (Member)
- Mathieu Bollen (Member)
- Xinyu Cao (Member)
- Zander Claes (Member)
- Monica Dos Santos Ferreira (Member)
- Marloes Jonkhout (Member)
- Sarah Lemaire (Member)
- Aleyde Van Eynde (Member)
Projects
1 - 10 of 41
- Phospho-regulation at the crossroads of cell proliferation and DNA-damage controlFrom1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
- Coordination of cell-cycle progression and DNA-damage repair by the protein phosphatase-1 regulator NIPP1From1 Mar 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Life-course regulators of protein phosphatase-1From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Host cell phosphatases in the life cycle of DNA virusesFrom1 Oct 2020 → TodayFunding: BOF - projects
- Dual function of SDS22 in the biogenesis of protein phosphatase-1 holoenzymesFrom14 Oct 2019 → 14 Oct 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Role of histone modifications in the life cycle of AAV2 and recombinant AAV-mediated transgene expressionFrom1 Oct 2019 → 27 Jan 2023Funding: FWO Strategic Basic Research Grant, BOF - doctoral mandates
- Chaperone-mediated biogenesis and activity regulation of protein phosphatase-1From3 Sep 2019 → 10 Jan 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Foundations, funds and other with scientific goal
- Targeting a timer-integrator of cell checkpoint signaling for mesothelioma therapyFrom1 Jan 2019 → 31 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular timers of the spindle assembly checkpointFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 128
- Neural stem cells: the need for a proper orientation(2010)
Authors: Bart Lesage
Pages: 438 - 442 - Biogenesis and activity regulation of protein phosphatase 1 (vol 45, pg 89, 2017)(2017)
Authors: Iris Verbinnen, Monica Ferreira, Mathieu Bollen
Pages: 583 - 584 - Regulation of the protein phosphatase scaffold RepoMan during the cell cycle(2020)
Authors: Maria Giulia Manzione, Mathieu Bollen, Junbin Qian
- The role of RepoMan in chromosome-dependent microtubule nucleation(2017)
Authors: Sofie De Munter, Monique Beullens, Mathieu Bollen
Pages: 181 - 181 - On the detection of newer Epo forms in serum and urine using isoelectric focusing(2008)
Authors: Mathieu Bollen, Monique Beullens
Pages: 754 - 755 - Expression of a Protein Phosphatase 1 Inhibitor, cdNIPP1, Increases CDK9 Threonine 186 Phosphorylation and Inhibits HIV-1 Transcription(2011)
Authors: Aleyde Van Eynde, Monique Beullens, Mathieu Bollen
Pages: 3798 - 3804 - Nuclear Inhibitor of Protein Phosphatase-1 (NIPP1) Directs Protein Phosphatase-1 (PP1) to Dephosphorylate the U2 Small Nuclear Ribonucleoprotein Particle (snRNP) Component, Spliceosome-associated Protein 155 (Sap155)(2008)
Authors: Monique Beullens, Mathieu Bollen
Pages: 35805 - 35814 - Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells(2009)
Authors: Silvia Jansen, Maria Andries, Katrien Vekemans, Alfons Verbruggen, Mathieu Bollen
Pages: 216 - 21 - Transcriptomics analysis reveals new insights in E171-induced molecular alterations in a mouse model of colon cancer(2018)
Authors: Heloise Proquin, Marlon J Jetten, Marloes Jonkhout, Luis Guillermo Garduno-Balderas, Jacob J Briede, Theo M de Kok, Henk van Loveren, Yolanda I Chirino
- Enhanced DNA-repair capacity and resistance to chemically induced carcinogenesis upon deletion of the phosphatase regulator NIPP1(2020)
Authors: Iris Verbinnen, Aleyde Van Eynde, Mathieu Bollen