Organisation
Experimental Cardiology
Division
Research focuses on molecular mechanisms of excitation-contraction coupling in cardiac myocytes (electrophysiology, advanced calcium imaging), cellular remodeling in cardiac disease: ischemia and heart failure, mechanisms of arrhythmias. Research further aims to understand epigenetic mechanisms of adaptive and maladaptive remodeling of cardiac myocytes. Other work focuses on molecular pathways in metabolic cardiovascular diseases and biomarkers.
Current researchers
1 - 10 of 17 results
- H Llewelyn Roderick (Responsible)
- Matthew Amoni (Member)
- Konstantinos Chatzieleftheriadis (Member)
- Joshua Jeen Tung Chung (Member)
- Fiona DE MATOS (Member)
- Rosa Donate Puertas (Member)
- Eef Dries (Member)
- Samaneh Ekhteraeitousi (Member)
- David Fajardo (Member)
- Yile Fu (Member)
Projects
1 - 10 of 54
- Deciphering Molecular Pathways of Hypoxia Sensitivity in Adult Cardiomyocytes: An Integrative Cross-Species InvestigationFrom1 Apr 2024 → TodayFunding: Other federal public and semi-governmental institutions
- Human Stem Cell-Derived Cardiac Models to Investigate Cell-Cell Interactions in Epicardial Activation and Cardiac RemodelingFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel ex vivo approach to study local Ca2+-induced triggered activities in ventricular arrhythmias using living adult cardiac slicesFrom1 Sep 2023 → TodayFunding: BOF - tenure track
- Connexin-43 Hemichannels as pro-arythmic mediators in Cardiac Hypertrophy and Heart FailureFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Understanding how neutrophil extracellular traps (NETs) contribute to vulnerability of the ageing heartFrom1 Oct 2022 → TodayFunding: FWO fellowships
- Investigating the role of DNA methylation in the failing and in the ageing heartFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Subcellular Ca2+ signalling microdomains regulating cardiomyocyte growth and functionsFrom19 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Interventional X-ray system equipped with 3D rotational angiography for cardiovascular research in preclinical large animal models.From1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Spatially-Organized 3D Human Cardiac Bilayer Models for Duchenne Cardiomyopathy Modelling and Drug DiscoveryFrom23 Nov 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Cell-cell interactions and the role of tissue microarchitecture in cardiac arrhythmias after myocardial infarctionFrom15 Nov 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
31 - 40 of 366
- R-DECO : An open-source Matlab based graphical user interface for the detection and correction of R-peaks(2019)
Authors: Jonathan Moeyersons, Matthew Amoni, Rik Willems, Sabine Van Huffel, Carolina Varon Perez
- The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor(2009)
Authors: Geert Bultynck, Jan Parys, Humbert De Smedt, H Llewelyn Roderick
Pages: 14397 - 14402 - Histological correlate of a cardiac magnetic resonance imaged microvascular obstruction in a porcine model of ischemia-reperfusion(2012)
Authors: Ronald Driesen, Jan Bogaert, Karin Sipido, Frans Van de Werf, Piet Claus
Pages: 129 - 131 - Can Body Surface Microvolt T-Wave Alternans Distinguish Concordant and Discordant Intracardiac Alternans?(2013)
Authors: Vincent Floré, Piet Claus, Rolf Symons, Karin Sipido, Rik Willems
Pages: 1007 - 1016 - Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity(2018)
Authors: Tim De Coster, Piet Claus, Rik Willems, Karin Sipido
- Calcium Signaling in Cardiomyocyte Function(2020)
Authors: Guillaume Gilbert, Kateryna Demydenko, Eef Dries, Karin Sipido, H Llewelyn Roderick
- The value of beat-to-beat variability of repolarisation and T-wave alternans as markers for arrhythmogenic remodeling early after myocardial infarction in a pig model(2010)
Authors: Vincent Floré, Piet Claus, Gudrun Antoons, Rik Willems
Pages: 263 - 264 - Hyperactive ryanodine receptors in human heart failure and ischaemic cardiomyopathy reside outside of couplons(2018)
Authors: Eef Dries, Guillaume Gilbert, Ilse Lenaerts, Bert Vandenberk, Daniel Johnson, H Llewelyn Roderick, Piet Claus, Karin Sipido
Pages: 1512 - 1524 - Trends in diagnosis, referral, red flag onset, patient profiles and natural outcome of de novo cardiac amyloidosis and their multidisciplinary implications(2022)
Authors: Mathias Claeys, Maarten De Smet, Sander Trenson
Pages: 791 - 804 - Mitochondrial respiration is reduced after myocardial infarction in chronic ischemic myocardium as well as in the remote non-ischemic region(2012)
Authors: Virginie Bito, Piet Claus, K Vermeulen, C Huysmans, R Ventura-Clapier
Pages: S69 - S69