Cell Metabolism

The primary objectives of the lab are 1) to understand the role of peroxisomes and in particular of peroxisomal β-oxidation in diverse tissues and during different stages of life 2) to investigate the pathological mechanisms in peroxisomal diseases which should allow the development of therapies. To approach these questions we generated a series of mouse models with global or cell type selective inactivation of functional peroxisomes or of the pivotal peroxisomal β-oxidation enzyme, multifunctional protein 2. During the last 2 decades, we have gathered a broad expertise in phenotyping these mouse models with peroxisome deficiencies.

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