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Researcher
Xavier Saelens
- Keywords (Ghent University):antiviral immunity, virology, vaccines
- Disciplines (Flanders Institute for Biotechnology):Analytical biochemistry, Cell death and senescence, Analysis of next-generation sequence data, General diagnostics
- Disciplines (Ghent University):Applied immunology, Drug discovery and development not elsewhere classified, Clinical trials, Biopharmaceuticals, In vitro testing, Non-clinical studies, Animal immunology, Transcription and translation, Vaccines, Molecular and cell biology not elsewhere classified, Virology
- See also: Xavier Saelens (Ghent University)
Affiliations
- Department of Biochemistry and microbiology (Department)
Member
From1 Oct 2018 → Today - Saelens Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Biomedical molecular biology (Department)
Member
From1 Jan 1996 → 30 Sep 2018 - Department of Plant Biotechnology and Bioinformatics (Department)
Member
From1 Jan 1993 → 31 Dec 1995
Projects
1 - 6 of 6
- Evolvable and rapidly adaptable monobodies: a broad-spectrum antiviral platform.From1 Jan 2024 → TodayFunding: Other EU initiatives out of framework
- VIB Grant for Saelens Lab_Period:2022-01-01-2026-12-31From1 Jan 2022 → TodayFunding: FRI - Project driven research
- Pichia for pandemic readiness VHH-Fc antibodiesFrom1 Dec 2021 → 29 Feb 2024Funding: Foreign foundations, funds with scientific view
- ExeVir's XVR011, a best in class nanobody-based biology that broadly neutralizes SARS-COV-1 and SARS-COV-2From1 Dec 2021 → 30 Nov 2022Funding: Other EU initiatives out of framework
- 'Evaluation of ratioNally Designed Influenza vaccines’ — ‘ENDFLU’From1 Aug 2020 → TodayFunding: Other EU initiatives out of framework
- VIB Grant for Saelens Lab_Period:2017-01-01-2021-12-31From1 Jan 2017 → 31 Dec 2021Funding: FRI - Project driven research
Publications
1 - 10 of 84
- Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline: caution is warranted.(2024)
Authors: Bert Schepens, Sieglinde De Cae, Koen Sedeyn, Hannah Eeckhaut, Daria Fijalkowska, Kenny Roose, Nico Callewaert, Han Remaut, Xavier Saelens
Pages: 104960 - Promises and challenges of single-domain antibodies to control influenza.(2024)
Authors: Arne Matthys, Xavier Saelens
Pages: 105807 - A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein.(2024)
Authors: Marlies Ballegeer, Shubham Pandey, Xavier Saelens
Pages: e-pub - Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins.(2023)
Authors: Francis Impens, Xavier Saelens, Kris Gevaert
Pages: 450 - Rethinking IL-1 Antagonism in Respiratory Viral Infections: A Role for IL-1 Signaling in the Development of Antiviral T Cell Immunity.(2023)
Authors: Marlies Ballegeer, Xavier Saelens
Pages: 15770 - Development of Digital Droplet PCR Targeting the Influenza H3N2 Oseltamivir-Resistant E119V Mutation and Its Performance through the Use of Reverse Genetics Mutants.(2023)
Authors: Laura Van Poelvoorde, Xavier Saelens
Pages: 2521-2532 - Epidemiology of influenza over a ten-year period in Belgium: overview of the historical and current evidence.(2023)
Authors: Xavier Saelens
Pages: 271 - GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery.(2023)
Authors: Loes van Schie, Wander Van Breedam, Charlotte Roels, Bert Schepens, Iebe Rossey, Karel Thooft, Xavier Saelens, Nico Callewaert
Pages: 2210709 - Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair.(2023)
Authors: Marlies Ballegeer, Xavier Saelens
Pages: eadg2829 - Anti-neuraminidase and anti-hemagglutinin immune serum can confer inter-lineage cross protection against recent influenza B.(2023)
Authors: Joao Paulo Portela Catani, Xavier Saelens
Pages: e0280825
Patents
1 - 10 of 10
- SARBECOVIRUS BINDERS (Inventor)
- CORONA VIRUS BINDERS (Inventor)
- CORONA VIRUS BINDERS (Inventor)
- PAN-SPECIFIC CORONA VIRUS BINDERS (Inventor)
- SARBECOVIRUS BINDERS (Inventor)
- ANTIBODY COMPOSITIONS FOR TREATMENT OF CORONA VIRUS INFECTION (Inventor)
- CORONA VIRUS BINDERS (Inventor)
- Methods of Generating Broadly Protective Vaccine Compositions Comprising Neuraminidase (Inventor)
- Methods of Generating Broadly Protective Vaccine Compositions Comprising Neuraminidase (Inventor)
- MIXED-LINEAGE KINASE DOMAIN-LIKE PROTEIN IN IMMUNOTHERAPEUTIC CANCER CONTROL (Inventor)