Next-generation immune biomarkers to improve clinical immunotherapy options for pediatric and adult patients with glioblastoma: a multi-omics, translational immunology and artificial intelligence-driven approach

The aim of this project is to present a clinically useful research protocol at the end of the 4 years that will use scientifically validated biomarkers to identify the most appropriate (combinations of) immunotherapies in a personalized way for every brain tumor patient, pediatric and adult. to select a clinical trial. To achieve this biomarker-based selection, combinations of the most advanced molecular cell biological research methods and bioinformatics analysis including artificial intelligence will be used, all of which are already available and applied in our research group.