Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages

The disclosure relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including single-domain antibodies (sdAbs), against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.

Patent Publication Number: US9556273

Year filing: 2013

Year approval: 2017

Validated for IOF-key: Yes

Attributed to: Universitaire Associatie Brussel