Radiolabelled antibody fragments for use in treating cancer

Provided herein are methods, kits, and compositions for stratifying and treating subjects, e.g., subjects having cancer. In some examples, the methods involve use of a radiolabelled heavy chain variable domain derived from a heavy chain antibody (VHH), or a functional fragment thereof, as both a screening agent and a treatment agent. In some examples, the VHH, or a functional fragment thereof, that is radiolabelled with a radioisotope that is both a γ-emitter and β-emitter.

Patent Publication Number: WO2017013026

Year filing: 2016

Year approval: 2018

Validated for IOF-key: Yes

Attributed to: Universitaire Associatie Brussel